Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems

PURPOSE: In vivo, the circadian clock drives 24-h rhythms in human physiology. Isolated cells in vitro retain a functional clockwork but lack necessary timing cues resulting in the rapid loss of tissue-level circadian rhythms. This study tests the hypothesis that repeated daily mechanical stimulatio...

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Detalles Bibliográficos
Autores principales: Heywood, Hannah K., Gardner, Laurence, Knight, Martin M., Lee, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Concepts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767245/
https://www.ncbi.nlm.nih.gov/pubmed/36570670
http://dx.doi.org/10.1007/s44164-022-00032-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767245/
https://www.ncbi.nlm.nih.gov/pubmed/36570670
http://dx.doi.org/10.1007/s44164-022-00032-x

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