Síntesis de evidencia y recomendaciones: directrices para la profilaxis y el manejo de pacientes con COVID-19 leve y moderada en América Latina y el Caribe

INTRODUCTION. Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Most infected people will experience mild to moderate respiratory illness. However, some will become seriously ill and require medical attention. Older people and those with certain comorbidities are more likely to develop serious illness. OBJECTIVE. To synthesize the recommendations included in Guidelines for Prophylaxis and Management of Patients with Mild and Moderate COVID-19 in Latin America and the Caribbean, and in Considerations on the Use of Antivirals, Monoclonal Antibodies, and Other Interventions for the Management of COVID-19 Patients in Latin America and the Caribbean, published by the Pan American Health Organization, in order to provide guidance on the prophylaxis and management of patients with mild to moderate COVID-19 and address key aspects of implementation. METHODS. The guidelines and their recommendations were summarized. In addition, a systematic search was carried out in PubMed, Lilacs, Health Systems Evidence, Epistemonikos, and gray literature on other studies carried out in the Region of the Americas, in order to identify barriers, facilitators, and implementation strategies. RESULTS. Twenty-one recommendations are presented, addressing the identification of markers and risk factors for mortality, prophylactic efficacy, pharmacological and non-pharmacological treatment, non-hospital management (including pregnant women and the pediatric population), use of diagnostic imaging studies, prophylaxis with anticoagulants, and follow-up. CONCLUSIONS. The recommendations seek to provide knowledge on the prophylaxis and management of patients with mild to moderate COVID-19 and offer considerations for implementation of the recommendations in the Region.