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Characteristics and predictors of Long COVID among diagnosed cases of COVID-19

BACKGROUND: Long COVID or long-term symptoms after COVID-19 has the ability to affect health and quality of life. Knowledge about the burden and predictors could aid in their prevention and management. Most of the studies are from high-income countries and focus on severe acute COVID-19 cases. We di...

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Autores principales: Arjun, M. C., Singh, Arvind Kumar, Pal, Debkumar, Das, Kajal, G., Alekhya, Venkateshan, Mahalingam, Mishra, Baijayantimala, Patro, Binod Kumar, Mohapatra, Prasanta Raghab, Subba, Sonu Hangma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767341/
https://www.ncbi.nlm.nih.gov/pubmed/36538532
http://dx.doi.org/10.1371/journal.pone.0278825
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author Arjun, M. C.
Singh, Arvind Kumar
Pal, Debkumar
Das, Kajal
G., Alekhya
Venkateshan, Mahalingam
Mishra, Baijayantimala
Patro, Binod Kumar
Mohapatra, Prasanta Raghab
Subba, Sonu Hangma
author_facet Arjun, M. C.
Singh, Arvind Kumar
Pal, Debkumar
Das, Kajal
G., Alekhya
Venkateshan, Mahalingam
Mishra, Baijayantimala
Patro, Binod Kumar
Mohapatra, Prasanta Raghab
Subba, Sonu Hangma
author_sort Arjun, M. C.
collection PubMed
description BACKGROUND: Long COVID or long-term symptoms after COVID-19 has the ability to affect health and quality of life. Knowledge about the burden and predictors could aid in their prevention and management. Most of the studies are from high-income countries and focus on severe acute COVID-19 cases. We did this study to estimate the incidence and identify the characteristics and predictors of Long COVID among our patients. METHODOLOGY: We recruited adult (≥18 years) patients who were diagnosed as Reverse Transcription Polymerase Chain Reaction (RTPCR) confirmed SARS-COV-2 infection and were either hospitalized or tested on outpatient basis. Eligible participants were followed up telephonically after four weeks and six months of diagnosis of SARS-COV-2 infection to collect data on sociodemographic, clinical history, vaccination history, Cycle threshold (Ct) values during diagnosis and other variables. Characteristics of Long COVID were elicited, and multivariable logistic regression was done to find the predictors of Long COVID. RESULTS: We have analyzed 487 and 371 individual data with a median follow-up of 44 days (Inter quartile range (IQR): 39,47) and 223 days (IQR:195,251), respectively. Overall, Long COVID was reported by 29.2% (95% Confidence interval (CI): 25.3%,33.4%) and 9.4% (95% CI: 6.7%,12.9%) of participants at four weeks and six months of follow-up, respectively. Incidence of Long COVID among patients with mild/moderate disease (n = 415) was 23.4% (95% CI: 19.5%,27.7%) as compared to 62.5% (95% CI: 50.7%,73%) in severe/critical cases(n = 72) at four weeks of follow-up. At six months, the incidence among mild/moderate (n = 319) was 7.2% (95% CI:4.6%,10.6%) as compared to 23.1% (95% CI:12.5%,36.8%) in severe/critical (n = 52). The most common Long COVID symptom was fatigue. Statistically significant predictors of Long COVID at four weeks of follow-up were—Pre-existing medical conditions (Adjusted Odds ratio (aOR) = 2.00, 95% CI: 1.16,3.44), having a higher number of symptoms during acute phase of COVID-19 disease (aOR = 11.24, 95% CI: 4.00,31.51), two doses of COVID-19 vaccination (aOR = 2.32, 95% CI: 1.17,4.58), the severity of illness (aOR = 5.71, 95% CI: 3.00,10.89) and being admitted to hospital (Odds ratio (OR) = 3.89, 95% CI: 2.49,6.08). CONCLUSION: A considerable proportion of COVID-19 cases reported Long COVID symptoms. More research is needed in Long COVID to objectively assess the symptoms and find the biological and radiological markers.
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spelling pubmed-97673412022-12-21 Characteristics and predictors of Long COVID among diagnosed cases of COVID-19 Arjun, M. C. Singh, Arvind Kumar Pal, Debkumar Das, Kajal G., Alekhya Venkateshan, Mahalingam Mishra, Baijayantimala Patro, Binod Kumar Mohapatra, Prasanta Raghab Subba, Sonu Hangma PLoS One Research Article BACKGROUND: Long COVID or long-term symptoms after COVID-19 has the ability to affect health and quality of life. Knowledge about the burden and predictors could aid in their prevention and management. Most of the studies are from high-income countries and focus on severe acute COVID-19 cases. We did this study to estimate the incidence and identify the characteristics and predictors of Long COVID among our patients. METHODOLOGY: We recruited adult (≥18 years) patients who were diagnosed as Reverse Transcription Polymerase Chain Reaction (RTPCR) confirmed SARS-COV-2 infection and were either hospitalized or tested on outpatient basis. Eligible participants were followed up telephonically after four weeks and six months of diagnosis of SARS-COV-2 infection to collect data on sociodemographic, clinical history, vaccination history, Cycle threshold (Ct) values during diagnosis and other variables. Characteristics of Long COVID were elicited, and multivariable logistic regression was done to find the predictors of Long COVID. RESULTS: We have analyzed 487 and 371 individual data with a median follow-up of 44 days (Inter quartile range (IQR): 39,47) and 223 days (IQR:195,251), respectively. Overall, Long COVID was reported by 29.2% (95% Confidence interval (CI): 25.3%,33.4%) and 9.4% (95% CI: 6.7%,12.9%) of participants at four weeks and six months of follow-up, respectively. Incidence of Long COVID among patients with mild/moderate disease (n = 415) was 23.4% (95% CI: 19.5%,27.7%) as compared to 62.5% (95% CI: 50.7%,73%) in severe/critical cases(n = 72) at four weeks of follow-up. At six months, the incidence among mild/moderate (n = 319) was 7.2% (95% CI:4.6%,10.6%) as compared to 23.1% (95% CI:12.5%,36.8%) in severe/critical (n = 52). The most common Long COVID symptom was fatigue. Statistically significant predictors of Long COVID at four weeks of follow-up were—Pre-existing medical conditions (Adjusted Odds ratio (aOR) = 2.00, 95% CI: 1.16,3.44), having a higher number of symptoms during acute phase of COVID-19 disease (aOR = 11.24, 95% CI: 4.00,31.51), two doses of COVID-19 vaccination (aOR = 2.32, 95% CI: 1.17,4.58), the severity of illness (aOR = 5.71, 95% CI: 3.00,10.89) and being admitted to hospital (Odds ratio (OR) = 3.89, 95% CI: 2.49,6.08). CONCLUSION: A considerable proportion of COVID-19 cases reported Long COVID symptoms. More research is needed in Long COVID to objectively assess the symptoms and find the biological and radiological markers. Public Library of Science 2022-12-20 /pmc/articles/PMC9767341/ /pubmed/36538532 http://dx.doi.org/10.1371/journal.pone.0278825 Text en © 2022 Arjun et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Arjun, M. C.
Singh, Arvind Kumar
Pal, Debkumar
Das, Kajal
G., Alekhya
Venkateshan, Mahalingam
Mishra, Baijayantimala
Patro, Binod Kumar
Mohapatra, Prasanta Raghab
Subba, Sonu Hangma
Characteristics and predictors of Long COVID among diagnosed cases of COVID-19
title Characteristics and predictors of Long COVID among diagnosed cases of COVID-19
title_full Characteristics and predictors of Long COVID among diagnosed cases of COVID-19
title_fullStr Characteristics and predictors of Long COVID among diagnosed cases of COVID-19
title_full_unstemmed Characteristics and predictors of Long COVID among diagnosed cases of COVID-19
title_short Characteristics and predictors of Long COVID among diagnosed cases of COVID-19
title_sort characteristics and predictors of long covid among diagnosed cases of covid-19
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767341/
https://www.ncbi.nlm.nih.gov/pubmed/36538532
http://dx.doi.org/10.1371/journal.pone.0278825
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