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Changes in genital Human Papillomavirus (HPV) prevalence among urban females a decade after the Malaysian HPV vaccination program

To increase the coverage of HPV vaccination, Malaysia implemented a national school-based vaccination program for all 13-year-old girls in 2010. Two years later, a clinic-based catch-up program was started for 16 to 21-year-old girls. We assessed the prevalence of a range of HPV genotypes, among a s...

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Autores principales: Khoo, Su Pei, Muhammad Ridzuan Tan, Nor Adriana, Rajasuriar, Reena, Nasir, Nazrila Hairizan, Gravitt, Patti, Ng, Chiu Wan, Woo, Yin Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767374/
https://www.ncbi.nlm.nih.gov/pubmed/36538522
http://dx.doi.org/10.1371/journal.pone.0278477
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author Khoo, Su Pei
Muhammad Ridzuan Tan, Nor Adriana
Rajasuriar, Reena
Nasir, Nazrila Hairizan
Gravitt, Patti
Ng, Chiu Wan
Woo, Yin Ling
author_facet Khoo, Su Pei
Muhammad Ridzuan Tan, Nor Adriana
Rajasuriar, Reena
Nasir, Nazrila Hairizan
Gravitt, Patti
Ng, Chiu Wan
Woo, Yin Ling
author_sort Khoo, Su Pei
collection PubMed
description To increase the coverage of HPV vaccination, Malaysia implemented a national school-based vaccination program for all 13-year-old girls in 2010. Two years later, a clinic-based catch-up program was started for 16 to 21-year-old girls. We assessed the prevalence of a range of HPV genotypes, among a sample of urban women within the age groups of 18–24 and 35–45 years in 2019–2020, a decade into the national vaccination program. The HPV prevalence was then compared to that reported in an unvaccinated population in 2013–2015. We sampled a total of 1134 participants, comprising of 277 women aged 18–24 years and 857 women aged 35–45 years, from several urban clinics in the state of Selangor. Participants provided a self-acquired vaginal sample for HPV genotyping. Comprehensive sociodemographic and vaccination history were collected. The HPV vaccination coverage among women in the younger age group increased from 9.3% in 2013–2015 to 75.5% in 2019–2020. The prevalence of vaccine-targeted HPV16/18 decreased 91% (CI: 14.5%–99.0%) among the younger women, from 4.0% in 2013–2015 to 0.4% in 2019–2020. There was also an 87% (CI: 27.5%–97.5%) reduction in HPV6/11/16/18. There was no difference in the prevalence of non-vaccine targeted HPV genotypes among younger women. The HPV prevalence among older women, for both vaccine targeted and non-vaccine targeted genotypes in 2019–2020, did not differ from 2013–2015. The observed decline in prevalence of vaccine-targeted HPV genotype among younger women a decade after the national HPV vaccination program is an early indication of its effectiveness in reducing the burden of cervical cancer.
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spelling pubmed-97673742022-12-21 Changes in genital Human Papillomavirus (HPV) prevalence among urban females a decade after the Malaysian HPV vaccination program Khoo, Su Pei Muhammad Ridzuan Tan, Nor Adriana Rajasuriar, Reena Nasir, Nazrila Hairizan Gravitt, Patti Ng, Chiu Wan Woo, Yin Ling PLoS One Research Article To increase the coverage of HPV vaccination, Malaysia implemented a national school-based vaccination program for all 13-year-old girls in 2010. Two years later, a clinic-based catch-up program was started for 16 to 21-year-old girls. We assessed the prevalence of a range of HPV genotypes, among a sample of urban women within the age groups of 18–24 and 35–45 years in 2019–2020, a decade into the national vaccination program. The HPV prevalence was then compared to that reported in an unvaccinated population in 2013–2015. We sampled a total of 1134 participants, comprising of 277 women aged 18–24 years and 857 women aged 35–45 years, from several urban clinics in the state of Selangor. Participants provided a self-acquired vaginal sample for HPV genotyping. Comprehensive sociodemographic and vaccination history were collected. The HPV vaccination coverage among women in the younger age group increased from 9.3% in 2013–2015 to 75.5% in 2019–2020. The prevalence of vaccine-targeted HPV16/18 decreased 91% (CI: 14.5%–99.0%) among the younger women, from 4.0% in 2013–2015 to 0.4% in 2019–2020. There was also an 87% (CI: 27.5%–97.5%) reduction in HPV6/11/16/18. There was no difference in the prevalence of non-vaccine targeted HPV genotypes among younger women. The HPV prevalence among older women, for both vaccine targeted and non-vaccine targeted genotypes in 2019–2020, did not differ from 2013–2015. The observed decline in prevalence of vaccine-targeted HPV genotype among younger women a decade after the national HPV vaccination program is an early indication of its effectiveness in reducing the burden of cervical cancer. Public Library of Science 2022-12-20 /pmc/articles/PMC9767374/ /pubmed/36538522 http://dx.doi.org/10.1371/journal.pone.0278477 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Khoo, Su Pei
Muhammad Ridzuan Tan, Nor Adriana
Rajasuriar, Reena
Nasir, Nazrila Hairizan
Gravitt, Patti
Ng, Chiu Wan
Woo, Yin Ling
Changes in genital Human Papillomavirus (HPV) prevalence among urban females a decade after the Malaysian HPV vaccination program
title Changes in genital Human Papillomavirus (HPV) prevalence among urban females a decade after the Malaysian HPV vaccination program
title_full Changes in genital Human Papillomavirus (HPV) prevalence among urban females a decade after the Malaysian HPV vaccination program
title_fullStr Changes in genital Human Papillomavirus (HPV) prevalence among urban females a decade after the Malaysian HPV vaccination program
title_full_unstemmed Changes in genital Human Papillomavirus (HPV) prevalence among urban females a decade after the Malaysian HPV vaccination program
title_short Changes in genital Human Papillomavirus (HPV) prevalence among urban females a decade after the Malaysian HPV vaccination program
title_sort changes in genital human papillomavirus (hpv) prevalence among urban females a decade after the malaysian hpv vaccination program
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767374/
https://www.ncbi.nlm.nih.gov/pubmed/36538522
http://dx.doi.org/10.1371/journal.pone.0278477
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