EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

EROS (essential for reactive oxygen species) protein is indispensable for expression of gp91phox, the catalytic core of the phagocyte NADPH oxidase. EROS deficiency in humans is a novel cause of the severe immunodeficiency, chronic granulomatous disease, but its mechanism of action was unknown until...

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Detalles Bibliográficos
Autores principales: Randzavola, Lyra O, Mortimer, Paige M, Garside, Emma, Dufficy, Elizabeth R, Schejtman, Andrea, Roumelioti, Georgia, Yu, Lu, Pardo, Mercedes, Spirohn, Kerstin, Tolley, Charlotte, Brandt, Cordelia, Harcourt, Katherine, Nichols, Esme, Nahorski, Mike, Woods, Geoff, Williamson, James C, Suresh, Shreehari, Sowerby, John M, Matsumoto, Misaki, Santos, Celio XC, Kiar, Cher Shen, Mukhopadhyay, Subhankar, Rae, William M, Dougan, Gordon J, Grainger, John, Lehner, Paul J, Calderwood, Michael A, Choudhary, Jyoti, Clare, Simon, Speak, Anneliese, Santilli, Giorgia, Bateman, Alex, Smith, Kenneth GC, Magnani, Francesca, Thomas, David C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767466/
https://www.ncbi.nlm.nih.gov/pubmed/36421765
http://dx.doi.org/10.7554/eLife.76387

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