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A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia
Dapsone is an antibiotic used in the management of dermatologic infections and opportunistic infection prophylaxis in developed countries. Methemoglobinemia (MetHb) is a known complication of dapsone use that can result in cyanosis. MetHb is an aberrant form of hemoglobin produced physiologically by...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767671/ https://www.ncbi.nlm.nih.gov/pubmed/36561581 http://dx.doi.org/10.7759/cureus.31684 |
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author | Khan Suheb, Mahammed Naaz, Farheen Anderson, Tyler K McClanahan, Alexander |
author_facet | Khan Suheb, Mahammed Naaz, Farheen Anderson, Tyler K McClanahan, Alexander |
author_sort | Khan Suheb, Mahammed |
collection | PubMed |
description | Dapsone is an antibiotic used in the management of dermatologic infections and opportunistic infection prophylaxis in developed countries. Methemoglobinemia (MetHb) is a known complication of dapsone use that can result in cyanosis. MetHb is an aberrant form of hemoglobin produced physiologically by auto-oxidation. An impairment in the process of auto-oxidation due to genetic defects or the use of drugs/toxins causes its levels to rise. Management involves timely recognition and the use of methylene blue (MB) or ascorbic acid. We describe the diagnosis and management of a patient with acquired MetHb as a result of dapsone use. |
format | Online Article Text |
id | pubmed-9767671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-97676712022-12-21 A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia Khan Suheb, Mahammed Naaz, Farheen Anderson, Tyler K McClanahan, Alexander Cureus Internal Medicine Dapsone is an antibiotic used in the management of dermatologic infections and opportunistic infection prophylaxis in developed countries. Methemoglobinemia (MetHb) is a known complication of dapsone use that can result in cyanosis. MetHb is an aberrant form of hemoglobin produced physiologically by auto-oxidation. An impairment in the process of auto-oxidation due to genetic defects or the use of drugs/toxins causes its levels to rise. Management involves timely recognition and the use of methylene blue (MB) or ascorbic acid. We describe the diagnosis and management of a patient with acquired MetHb as a result of dapsone use. Cureus 2022-11-19 /pmc/articles/PMC9767671/ /pubmed/36561581 http://dx.doi.org/10.7759/cureus.31684 Text en Copyright © 2022, Khan Suheb et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Khan Suheb, Mahammed Naaz, Farheen Anderson, Tyler K McClanahan, Alexander A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia |
title | A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia |
title_full | A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia |
title_fullStr | A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia |
title_full_unstemmed | A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia |
title_short | A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia |
title_sort | case of cyanosis with saturation gap: dapsone-induced methemoglobinemia |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767671/ https://www.ncbi.nlm.nih.gov/pubmed/36561581 http://dx.doi.org/10.7759/cureus.31684 |
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