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A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia

Dapsone is an antibiotic used in the management of dermatologic infections and opportunistic infection prophylaxis in developed countries. Methemoglobinemia (MetHb) is a known complication of dapsone use that can result in cyanosis. MetHb is an aberrant form of hemoglobin produced physiologically by...

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Detalles Bibliográficos
Autores principales: Khan Suheb, Mahammed, Naaz, Farheen, Anderson, Tyler K, McClanahan, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767671/
https://www.ncbi.nlm.nih.gov/pubmed/36561581
http://dx.doi.org/10.7759/cureus.31684
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author Khan Suheb, Mahammed
Naaz, Farheen
Anderson, Tyler K
McClanahan, Alexander
author_facet Khan Suheb, Mahammed
Naaz, Farheen
Anderson, Tyler K
McClanahan, Alexander
author_sort Khan Suheb, Mahammed
collection PubMed
description Dapsone is an antibiotic used in the management of dermatologic infections and opportunistic infection prophylaxis in developed countries. Methemoglobinemia (MetHb) is a known complication of dapsone use that can result in cyanosis. MetHb is an aberrant form of hemoglobin produced physiologically by auto-oxidation. An impairment in the process of auto-oxidation due to genetic defects or the use of drugs/toxins causes its levels to rise. Management involves timely recognition and the use of methylene blue (MB) or ascorbic acid. We describe the diagnosis and management of a patient with acquired MetHb as a result of dapsone use.
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spelling pubmed-97676712022-12-21 A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia Khan Suheb, Mahammed Naaz, Farheen Anderson, Tyler K McClanahan, Alexander Cureus Internal Medicine Dapsone is an antibiotic used in the management of dermatologic infections and opportunistic infection prophylaxis in developed countries. Methemoglobinemia (MetHb) is a known complication of dapsone use that can result in cyanosis. MetHb is an aberrant form of hemoglobin produced physiologically by auto-oxidation. An impairment in the process of auto-oxidation due to genetic defects or the use of drugs/toxins causes its levels to rise. Management involves timely recognition and the use of methylene blue (MB) or ascorbic acid. We describe the diagnosis and management of a patient with acquired MetHb as a result of dapsone use. Cureus 2022-11-19 /pmc/articles/PMC9767671/ /pubmed/36561581 http://dx.doi.org/10.7759/cureus.31684 Text en Copyright © 2022, Khan Suheb et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Khan Suheb, Mahammed
Naaz, Farheen
Anderson, Tyler K
McClanahan, Alexander
A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia
title A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia
title_full A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia
title_fullStr A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia
title_full_unstemmed A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia
title_short A Case of Cyanosis With Saturation Gap: Dapsone-Induced Methemoglobinemia
title_sort case of cyanosis with saturation gap: dapsone-induced methemoglobinemia
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767671/
https://www.ncbi.nlm.nih.gov/pubmed/36561581
http://dx.doi.org/10.7759/cureus.31684
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