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Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral Pathogens

Dental caries is considered one of the most prevalent oral diseases worldwide, with a high rate of morbidity among populations. It is a chronic infectious disease with a multifactorial etiology that leads to the destruction of the dental tissues. Due to their antimicrobial, anti-inflammatory, antifu...

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Autores principales: Ahmed, Omnia, Sibuyi, Nicole R. S., Fadaka, Adewale O., Madiehe, Abram M., Maboza, Ernest, Olivier, Annette, Meyer, Mervin, Geerts, Greta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767746/
https://www.ncbi.nlm.nih.gov/pubmed/36561898
http://dx.doi.org/10.1155/2022/9602325
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author Ahmed, Omnia
Sibuyi, Nicole R. S.
Fadaka, Adewale O.
Madiehe, Abram M.
Maboza, Ernest
Olivier, Annette
Meyer, Mervin
Geerts, Greta
author_facet Ahmed, Omnia
Sibuyi, Nicole R. S.
Fadaka, Adewale O.
Madiehe, Abram M.
Maboza, Ernest
Olivier, Annette
Meyer, Mervin
Geerts, Greta
author_sort Ahmed, Omnia
collection PubMed
description Dental caries is considered one of the most prevalent oral diseases worldwide, with a high rate of morbidity among populations. It is a chronic infectious disease with a multifactorial etiology that leads to the destruction of the dental tissues. Due to their antimicrobial, anti-inflammatory, antifungal, and antioxidant properties; silver nanoparticles (AgNPs) are incorporated in dental products to help prevent infectious oral diseases. In this study, the antimicrobial effects of AgNPs synthesized using Gum Arabic extracts (GAE) were examined. The GA-AgNPs were synthesized and characterized using ultraviolet-visible (UV-Vis) spectrophotometer, dynamic light scattering (DLS), transmission electron microscopy (TEM), and Fourier transform infrared (FTIR) spectroscopy. The antimicrobial activity of the GA-AgNPs was evaluated on Streptococcus sanguinis (S. sanguinis), Streptococcus mutans (S. mutans), Lactobacillus acidophilus (L. acidophilus), and Candida albicans (C. albicans) using agar disc diffusion and microdilution assays. The antibiofilm of GA-AgNPs was evaluated on the surface of human tooth enamel that had been exposed to S. mutans with and without the GA-AgNPs using scanning electron microscopy (SEM). GA-AgNPs were spherical in shape with a particle size distribution between 4 and 26 nm. The GA-AgNPs exhibited antimicrobial activity against all the tested oral microbes, with GA-AgNPs_0.4g having higher antimicrobial activity. The GA-AgNPs_0.4g inhibited S. mutans adhesion and biofilm formation on the surface of the tooth enamel. Therefore, this study supports the prospective implementation of the plant extract-mediated AgNPs in dental healthcare.
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spelling pubmed-97677462022-12-21 Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral Pathogens Ahmed, Omnia Sibuyi, Nicole R. S. Fadaka, Adewale O. Madiehe, Abram M. Maboza, Ernest Olivier, Annette Meyer, Mervin Geerts, Greta Bioinorg Chem Appl Research Article Dental caries is considered one of the most prevalent oral diseases worldwide, with a high rate of morbidity among populations. It is a chronic infectious disease with a multifactorial etiology that leads to the destruction of the dental tissues. Due to their antimicrobial, anti-inflammatory, antifungal, and antioxidant properties; silver nanoparticles (AgNPs) are incorporated in dental products to help prevent infectious oral diseases. In this study, the antimicrobial effects of AgNPs synthesized using Gum Arabic extracts (GAE) were examined. The GA-AgNPs were synthesized and characterized using ultraviolet-visible (UV-Vis) spectrophotometer, dynamic light scattering (DLS), transmission electron microscopy (TEM), and Fourier transform infrared (FTIR) spectroscopy. The antimicrobial activity of the GA-AgNPs was evaluated on Streptococcus sanguinis (S. sanguinis), Streptococcus mutans (S. mutans), Lactobacillus acidophilus (L. acidophilus), and Candida albicans (C. albicans) using agar disc diffusion and microdilution assays. The antibiofilm of GA-AgNPs was evaluated on the surface of human tooth enamel that had been exposed to S. mutans with and without the GA-AgNPs using scanning electron microscopy (SEM). GA-AgNPs were spherical in shape with a particle size distribution between 4 and 26 nm. The GA-AgNPs exhibited antimicrobial activity against all the tested oral microbes, with GA-AgNPs_0.4g having higher antimicrobial activity. The GA-AgNPs_0.4g inhibited S. mutans adhesion and biofilm formation on the surface of the tooth enamel. Therefore, this study supports the prospective implementation of the plant extract-mediated AgNPs in dental healthcare. Hindawi 2022-12-13 /pmc/articles/PMC9767746/ /pubmed/36561898 http://dx.doi.org/10.1155/2022/9602325 Text en Copyright © 2022 Omnia Ahmed et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ahmed, Omnia
Sibuyi, Nicole R. S.
Fadaka, Adewale O.
Madiehe, Abram M.
Maboza, Ernest
Olivier, Annette
Meyer, Mervin
Geerts, Greta
Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral Pathogens
title Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral Pathogens
title_full Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral Pathogens
title_fullStr Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral Pathogens
title_full_unstemmed Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral Pathogens
title_short Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral Pathogens
title_sort antimicrobial effects of gum arabic-silver nanoparticles against oral pathogens
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767746/
https://www.ncbi.nlm.nih.gov/pubmed/36561898
http://dx.doi.org/10.1155/2022/9602325
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