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Efficacy of bone graft as monotherapy and in combination with platelet concentrates in grade II furcation defect – A systematic review and meta-analysis
BACKGROUND: The use of autologous platelet concentrates (PC) in addition to bone graft (BG) in open flap debridement (OFD) has been investigated to improve the efficacy and outcomes of regenerative therapy for furcation defects. This systematic review evaluated efficacy of added benefits of PC to bo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767862/ https://www.ncbi.nlm.nih.gov/pubmed/36570585 http://dx.doi.org/10.1016/j.sdentj.2022.10.001 |
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author | Bajaj, Vinisha Ashok Kolte, Abhay Pandurang Kolte, Rajashri Abhay |
author_facet | Bajaj, Vinisha Ashok Kolte, Abhay Pandurang Kolte, Rajashri Abhay |
author_sort | Bajaj, Vinisha Ashok |
collection | PubMed |
description | BACKGROUND: The use of autologous platelet concentrates (PC) in addition to bone graft (BG) in open flap debridement (OFD) has been investigated to improve the efficacy and outcomes of regenerative therapy for furcation defects. This systematic review evaluated efficacy of added benefits of PC to bone grafts in treatment of grade II furcation defects. METHODS: A thorough literature search on PubMed, Cochrane Library and Google Scholar databases was conducted. Data on outcomes were extracted only from randomized controlled clinical trials on humans with a minimum follow up of 6 months comparing BG alone and BG + PC in treatment of mandibular grade II furcation defect. RESULTS: 36 of the 518 screened articles and abstracts were read in full-text, nine of which have been included in the meta-analysis. The addition of PC to BG has resulted in improvement in PD, GR (with smaller effect); V-DBD and H-DBD showed smaller change in experimental group whereas VCAL and HCAL exhibited overall larger changes with smaller effect. CONCLUSION: Bone regeneration in terms of defect fill with the addition of platelet concentrates to bone graft remains debatable considering the minimal benefits in the treatment of grade II mandibular furcation defect. |
format | Online Article Text |
id | pubmed-9767862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-97678622022-12-22 Efficacy of bone graft as monotherapy and in combination with platelet concentrates in grade II furcation defect – A systematic review and meta-analysis Bajaj, Vinisha Ashok Kolte, Abhay Pandurang Kolte, Rajashri Abhay Saudi Dent J Review Article BACKGROUND: The use of autologous platelet concentrates (PC) in addition to bone graft (BG) in open flap debridement (OFD) has been investigated to improve the efficacy and outcomes of regenerative therapy for furcation defects. This systematic review evaluated efficacy of added benefits of PC to bone grafts in treatment of grade II furcation defects. METHODS: A thorough literature search on PubMed, Cochrane Library and Google Scholar databases was conducted. Data on outcomes were extracted only from randomized controlled clinical trials on humans with a minimum follow up of 6 months comparing BG alone and BG + PC in treatment of mandibular grade II furcation defect. RESULTS: 36 of the 518 screened articles and abstracts were read in full-text, nine of which have been included in the meta-analysis. The addition of PC to BG has resulted in improvement in PD, GR (with smaller effect); V-DBD and H-DBD showed smaller change in experimental group whereas VCAL and HCAL exhibited overall larger changes with smaller effect. CONCLUSION: Bone regeneration in terms of defect fill with the addition of platelet concentrates to bone graft remains debatable considering the minimal benefits in the treatment of grade II mandibular furcation defect. Elsevier 2022-12 2022-10-07 /pmc/articles/PMC9767862/ /pubmed/36570585 http://dx.doi.org/10.1016/j.sdentj.2022.10.001 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Bajaj, Vinisha Ashok Kolte, Abhay Pandurang Kolte, Rajashri Abhay Efficacy of bone graft as monotherapy and in combination with platelet concentrates in grade II furcation defect – A systematic review and meta-analysis |
title | Efficacy of bone graft as monotherapy and in combination with platelet concentrates in grade II furcation defect – A systematic review and meta-analysis |
title_full | Efficacy of bone graft as monotherapy and in combination with platelet concentrates in grade II furcation defect – A systematic review and meta-analysis |
title_fullStr | Efficacy of bone graft as monotherapy and in combination with platelet concentrates in grade II furcation defect – A systematic review and meta-analysis |
title_full_unstemmed | Efficacy of bone graft as monotherapy and in combination with platelet concentrates in grade II furcation defect – A systematic review and meta-analysis |
title_short | Efficacy of bone graft as monotherapy and in combination with platelet concentrates in grade II furcation defect – A systematic review and meta-analysis |
title_sort | efficacy of bone graft as monotherapy and in combination with platelet concentrates in grade ii furcation defect – a systematic review and meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767862/ https://www.ncbi.nlm.nih.gov/pubmed/36570585 http://dx.doi.org/10.1016/j.sdentj.2022.10.001 |
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