Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer

Solid tumors are generally characterized by an acidic tumor microenvironment (TME) that favors cancer progression, therapy resistance and immune evasion. By single-cell RNA-sequencing analysis in individuals with pancreatic ductal adenocarcinoma (PDAC), we reveal solute carrier family 4 member 4 (SL...

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Detalles Bibliográficos
Autores principales: Cappellesso, Federica, Orban, Marie-Pauline, Shirgaonkar, Niranjan, Berardi, Emanuele, Serneels, Jens, Neveu, Marie-Aline, Di Molfetta, Daria, Piccapane, Francesca, Caroppo, Rosa, Debellis, Lucantonio, Ostyn, Tessa, Joudiou, Nicolas, Mignion, Lionel, Richiardone, Elena, Jordan, Bénédicte F., Gallez, Bernard, Corbet, Cyril, Roskams, Tania, DasGupta, Ramanuj, Tejpar, Sabine, Di Matteo, Mario, Taverna, Daniela, Reshkin, Stephan J., Topal, Baki, Virga, Federico, Mazzone, Massimiliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767871/
https://www.ncbi.nlm.nih.gov/pubmed/36522548
http://dx.doi.org/10.1038/s43018-022-00470-2

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