Protein re-surfacing of E. coli L-Asparaginase to evade pre-existing anti-drug antibodies and hypersensitivity responses

The optimal use of many biotherapeutics is restricted by Anti-drug antibodies (ADAs) and hypersensitivity responses which can affect potency and ability to administer a treatment. Here we demonstrate that Re-surfacing can be utilized as a generalizable approach to engineer proteins with extensive su...

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Detalles Bibliográficos
Autores principales: Bootwala, Ali, An, Hyun Hwan, Franklin, Meghan Whitney, Manning, Benjamin J., Xu, Lucy Y., Panchal, Shruti, Garlick, Joseph D., Baral, Reshica, Hudson, Michael E., Grigoryan, Gevorg, Murakami, Mark A., Hopson, Kristen, Leventhal, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767956/
https://www.ncbi.nlm.nih.gov/pubmed/36569945
http://dx.doi.org/10.3389/fimmu.2022.1016179

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