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Alteration of whole-brain amplitude of low-frequency fluctuation and degree centrality in patients with mild to moderate depression: A resting-state functional magnetic resonance imaging study

BACKGROUND: Mild to moderate depressive disorder has a high risk of progressing to major depressive disorder. METHODS: Low-frequency amplitude and degree centrality were calculated to compare 49 patients with mild to moderate depression and 21 matched healthy controls. Correlation analysis was condu...

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Autores principales: Chen, Fenyang, Wang, Luoyu, Ding, Zhongxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768018/
https://www.ncbi.nlm.nih.gov/pubmed/36569607
http://dx.doi.org/10.3389/fpsyt.2022.1061359
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author Chen, Fenyang
Wang, Luoyu
Ding, Zhongxiang
author_facet Chen, Fenyang
Wang, Luoyu
Ding, Zhongxiang
author_sort Chen, Fenyang
collection PubMed
description BACKGROUND: Mild to moderate depressive disorder has a high risk of progressing to major depressive disorder. METHODS: Low-frequency amplitude and degree centrality were calculated to compare 49 patients with mild to moderate depression and 21 matched healthy controls. Correlation analysis was conducted to explore the correlation between the amplitude of low-frequency fluctuation (ALFF) and the degree centrality (DC) of altered brain region and the scores of clinical scale. Receiver operating characteristic (ROC) curves were further analyzed to evaluate the predictive value of above altered ALFF and DC areas as image markers for mild to moderate depression. RESULTS: Compared with healthy controls, patients with mild to moderate depression had lower ALFF values in the left precuneus and posterior cingulate gyrus [voxel p < 0.005, cluster p < 0.05, Gaussian random field correction (GRF) corrected] and lower DC values in the left insula (voxel p < 0.005, cluster p < 0.05, GRF corrected). There was a significant negative correlation between DC in the left insula and scale scores of Zung’s Depression Scale (ZungSDS), Beck Self-Rating Depression Scale (BDI), Toronto Alexithymia Scale (TAS26), and Ruminative Thinking Response Scale (RRS_SUM, RRS_REFLECTION, RRS_DEPR). Finally, ROC analysis showed that the ALFF of the left precuneus and posterior cingulate gyrus had a sensitivity of 61.9% and a specificity of 79.6%, and the DC of the left insula had a sensitivity of 81% and a specificity of 85.7% in differentiating mild to moderate depression from healthy controls. CONCLUSION: Intrinsic abnormality of the brain was mainly located in the precuneus and insular in patients with mild to moderate depression, which provides insight into potential neurological mechanisms.
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spelling pubmed-97680182022-12-22 Alteration of whole-brain amplitude of low-frequency fluctuation and degree centrality in patients with mild to moderate depression: A resting-state functional magnetic resonance imaging study Chen, Fenyang Wang, Luoyu Ding, Zhongxiang Front Psychiatry Psychiatry BACKGROUND: Mild to moderate depressive disorder has a high risk of progressing to major depressive disorder. METHODS: Low-frequency amplitude and degree centrality were calculated to compare 49 patients with mild to moderate depression and 21 matched healthy controls. Correlation analysis was conducted to explore the correlation between the amplitude of low-frequency fluctuation (ALFF) and the degree centrality (DC) of altered brain region and the scores of clinical scale. Receiver operating characteristic (ROC) curves were further analyzed to evaluate the predictive value of above altered ALFF and DC areas as image markers for mild to moderate depression. RESULTS: Compared with healthy controls, patients with mild to moderate depression had lower ALFF values in the left precuneus and posterior cingulate gyrus [voxel p < 0.005, cluster p < 0.05, Gaussian random field correction (GRF) corrected] and lower DC values in the left insula (voxel p < 0.005, cluster p < 0.05, GRF corrected). There was a significant negative correlation between DC in the left insula and scale scores of Zung’s Depression Scale (ZungSDS), Beck Self-Rating Depression Scale (BDI), Toronto Alexithymia Scale (TAS26), and Ruminative Thinking Response Scale (RRS_SUM, RRS_REFLECTION, RRS_DEPR). Finally, ROC analysis showed that the ALFF of the left precuneus and posterior cingulate gyrus had a sensitivity of 61.9% and a specificity of 79.6%, and the DC of the left insula had a sensitivity of 81% and a specificity of 85.7% in differentiating mild to moderate depression from healthy controls. CONCLUSION: Intrinsic abnormality of the brain was mainly located in the precuneus and insular in patients with mild to moderate depression, which provides insight into potential neurological mechanisms. Frontiers Media S.A. 2022-12-07 /pmc/articles/PMC9768018/ /pubmed/36569607 http://dx.doi.org/10.3389/fpsyt.2022.1061359 Text en Copyright © 2022 Chen, Wang and Ding. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Chen, Fenyang
Wang, Luoyu
Ding, Zhongxiang
Alteration of whole-brain amplitude of low-frequency fluctuation and degree centrality in patients with mild to moderate depression: A resting-state functional magnetic resonance imaging study
title Alteration of whole-brain amplitude of low-frequency fluctuation and degree centrality in patients with mild to moderate depression: A resting-state functional magnetic resonance imaging study
title_full Alteration of whole-brain amplitude of low-frequency fluctuation and degree centrality in patients with mild to moderate depression: A resting-state functional magnetic resonance imaging study
title_fullStr Alteration of whole-brain amplitude of low-frequency fluctuation and degree centrality in patients with mild to moderate depression: A resting-state functional magnetic resonance imaging study
title_full_unstemmed Alteration of whole-brain amplitude of low-frequency fluctuation and degree centrality in patients with mild to moderate depression: A resting-state functional magnetic resonance imaging study
title_short Alteration of whole-brain amplitude of low-frequency fluctuation and degree centrality in patients with mild to moderate depression: A resting-state functional magnetic resonance imaging study
title_sort alteration of whole-brain amplitude of low-frequency fluctuation and degree centrality in patients with mild to moderate depression: a resting-state functional magnetic resonance imaging study
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768018/
https://www.ncbi.nlm.nih.gov/pubmed/36569607
http://dx.doi.org/10.3389/fpsyt.2022.1061359
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