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Using blood test parameters to define biological age among older adults: association with morbidity and mortality independent of chronological age validated in two separate birth cohorts

Biomarkers defining biological age are typically laborious or expensive to assess. Instead, in the current study, we identified parameters based on standard laboratory blood tests across metabolic, cardiovascular, inflammatory, and kidney functioning that had been assessed in the Berlin Aging Study...

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Autores principales: Drewelies, Johanna, Hueluer, Gizem, Duezel, Sandra, Vetter, Valentin Max, Pawelec, Graham, Steinhagen-Thiessen, Elisabeth, Wagner, Gert G., Lindenberger, Ulman, Lill, Christina M., Bertram, Lars, Gerstorf, Denis, Demuth, Ilja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768057/
https://www.ncbi.nlm.nih.gov/pubmed/36151431
http://dx.doi.org/10.1007/s11357-022-00662-9
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author Drewelies, Johanna
Hueluer, Gizem
Duezel, Sandra
Vetter, Valentin Max
Pawelec, Graham
Steinhagen-Thiessen, Elisabeth
Wagner, Gert G.
Lindenberger, Ulman
Lill, Christina M.
Bertram, Lars
Gerstorf, Denis
Demuth, Ilja
author_facet Drewelies, Johanna
Hueluer, Gizem
Duezel, Sandra
Vetter, Valentin Max
Pawelec, Graham
Steinhagen-Thiessen, Elisabeth
Wagner, Gert G.
Lindenberger, Ulman
Lill, Christina M.
Bertram, Lars
Gerstorf, Denis
Demuth, Ilja
author_sort Drewelies, Johanna
collection PubMed
description Biomarkers defining biological age are typically laborious or expensive to assess. Instead, in the current study, we identified parameters based on standard laboratory blood tests across metabolic, cardiovascular, inflammatory, and kidney functioning that had been assessed in the Berlin Aging Study (BASE) (n = 384) and Berlin Aging Study II (BASE-II) (n = 1517). We calculated biological age using those 12 parameters that individually predicted mortality hazards over 26 years in BASE. In BASE, older biological age was associated with more physician-observed morbidity and higher mortality hazards, over and above the effects of chronological age, sex, and education. Similarly, in BASE-II, biological age was associated with physician-observed morbidity and subjective health, over and above the effects of chronological age, sex, and education as well as alternative biomarkers including telomere length, DNA methylation age, skin age, and subjective age but not PhenoAge. We discuss the importance of biological age as one indicator of aging. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11357-022-00662-9.
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spelling pubmed-97680572022-12-22 Using blood test parameters to define biological age among older adults: association with morbidity and mortality independent of chronological age validated in two separate birth cohorts Drewelies, Johanna Hueluer, Gizem Duezel, Sandra Vetter, Valentin Max Pawelec, Graham Steinhagen-Thiessen, Elisabeth Wagner, Gert G. Lindenberger, Ulman Lill, Christina M. Bertram, Lars Gerstorf, Denis Demuth, Ilja GeroScience Original Article Biomarkers defining biological age are typically laborious or expensive to assess. Instead, in the current study, we identified parameters based on standard laboratory blood tests across metabolic, cardiovascular, inflammatory, and kidney functioning that had been assessed in the Berlin Aging Study (BASE) (n = 384) and Berlin Aging Study II (BASE-II) (n = 1517). We calculated biological age using those 12 parameters that individually predicted mortality hazards over 26 years in BASE. In BASE, older biological age was associated with more physician-observed morbidity and higher mortality hazards, over and above the effects of chronological age, sex, and education. Similarly, in BASE-II, biological age was associated with physician-observed morbidity and subjective health, over and above the effects of chronological age, sex, and education as well as alternative biomarkers including telomere length, DNA methylation age, skin age, and subjective age but not PhenoAge. We discuss the importance of biological age as one indicator of aging. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11357-022-00662-9. Springer International Publishing 2022-09-24 /pmc/articles/PMC9768057/ /pubmed/36151431 http://dx.doi.org/10.1007/s11357-022-00662-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Drewelies, Johanna
Hueluer, Gizem
Duezel, Sandra
Vetter, Valentin Max
Pawelec, Graham
Steinhagen-Thiessen, Elisabeth
Wagner, Gert G.
Lindenberger, Ulman
Lill, Christina M.
Bertram, Lars
Gerstorf, Denis
Demuth, Ilja
Using blood test parameters to define biological age among older adults: association with morbidity and mortality independent of chronological age validated in two separate birth cohorts
title Using blood test parameters to define biological age among older adults: association with morbidity and mortality independent of chronological age validated in two separate birth cohorts
title_full Using blood test parameters to define biological age among older adults: association with morbidity and mortality independent of chronological age validated in two separate birth cohorts
title_fullStr Using blood test parameters to define biological age among older adults: association with morbidity and mortality independent of chronological age validated in two separate birth cohorts
title_full_unstemmed Using blood test parameters to define biological age among older adults: association with morbidity and mortality independent of chronological age validated in two separate birth cohorts
title_short Using blood test parameters to define biological age among older adults: association with morbidity and mortality independent of chronological age validated in two separate birth cohorts
title_sort using blood test parameters to define biological age among older adults: association with morbidity and mortality independent of chronological age validated in two separate birth cohorts
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768057/
https://www.ncbi.nlm.nih.gov/pubmed/36151431
http://dx.doi.org/10.1007/s11357-022-00662-9
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