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Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study
Cellular senescence is a plausible mediator of age-associated declines in physical performance. To test this premise, we examined cross-sectional associations between circulating components of the senescence-associated secretory phenotype (SASP) and measures of physical function and muscle strength...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768064/ https://www.ncbi.nlm.nih.gov/pubmed/36367600 http://dx.doi.org/10.1007/s11357-022-00685-2 |
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author | Fielding, Roger A. Atkinson, Elizabeth J. Aversa, Zaira White, Thomas A. Heeren, Amanda A. Achenbach, Sara J. Mielke, Michelle M. Cummings, Steven R. Pahor, Marco Leeuwenburgh, Christiaan LeBrasseur, Nathan K. |
author_facet | Fielding, Roger A. Atkinson, Elizabeth J. Aversa, Zaira White, Thomas A. Heeren, Amanda A. Achenbach, Sara J. Mielke, Michelle M. Cummings, Steven R. Pahor, Marco Leeuwenburgh, Christiaan LeBrasseur, Nathan K. |
author_sort | Fielding, Roger A. |
collection | PubMed |
description | Cellular senescence is a plausible mediator of age-associated declines in physical performance. To test this premise, we examined cross-sectional associations between circulating components of the senescence-associated secretory phenotype (SASP) and measures of physical function and muscle strength in 1377 older adults. We showed significant associations between multiple SASP proteins and the short physical performance battery (SPPB), its subcomponents (gait speed, balance, chair rise time), and 400-m walk time. Activin A, ICAM1, MMP7, VEGFA, and eotaxin showed strong associations based on gradient boost machine learning (GBM), and, when combined with other proteins, effectively identified participants at the greatest risk for mobility disability (SPPB score [Formula: see text] 7). Senescence biomarkers were also associated with lower grip strength, and GBM identified PARC, ADAMTS13, and RANTES as top candidates in females, and MMP2, SOST, and MCP1 in males. These findings highlight an association between senescence biomarkers and physical performance in older adults. ClinicalTrials.gov Identifier: NCT01072500. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11357-022-00685-2. |
format | Online Article Text |
id | pubmed-9768064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-97680642022-12-22 Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study Fielding, Roger A. Atkinson, Elizabeth J. Aversa, Zaira White, Thomas A. Heeren, Amanda A. Achenbach, Sara J. Mielke, Michelle M. Cummings, Steven R. Pahor, Marco Leeuwenburgh, Christiaan LeBrasseur, Nathan K. GeroScience Original Article Cellular senescence is a plausible mediator of age-associated declines in physical performance. To test this premise, we examined cross-sectional associations between circulating components of the senescence-associated secretory phenotype (SASP) and measures of physical function and muscle strength in 1377 older adults. We showed significant associations between multiple SASP proteins and the short physical performance battery (SPPB), its subcomponents (gait speed, balance, chair rise time), and 400-m walk time. Activin A, ICAM1, MMP7, VEGFA, and eotaxin showed strong associations based on gradient boost machine learning (GBM), and, when combined with other proteins, effectively identified participants at the greatest risk for mobility disability (SPPB score [Formula: see text] 7). Senescence biomarkers were also associated with lower grip strength, and GBM identified PARC, ADAMTS13, and RANTES as top candidates in females, and MMP2, SOST, and MCP1 in males. These findings highlight an association between senescence biomarkers and physical performance in older adults. ClinicalTrials.gov Identifier: NCT01072500. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11357-022-00685-2. Springer International Publishing 2022-11-11 /pmc/articles/PMC9768064/ /pubmed/36367600 http://dx.doi.org/10.1007/s11357-022-00685-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Fielding, Roger A. Atkinson, Elizabeth J. Aversa, Zaira White, Thomas A. Heeren, Amanda A. Achenbach, Sara J. Mielke, Michelle M. Cummings, Steven R. Pahor, Marco Leeuwenburgh, Christiaan LeBrasseur, Nathan K. Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study |
title | Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study |
title_full | Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study |
title_fullStr | Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study |
title_full_unstemmed | Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study |
title_short | Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study |
title_sort | associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (life) study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768064/ https://www.ncbi.nlm.nih.gov/pubmed/36367600 http://dx.doi.org/10.1007/s11357-022-00685-2 |
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