JAG1 is associated with the prognosis and metastasis in breast cancer

Jagged canonical Notch ligand 1 (JAG1) regulates the progression of many cancers by the Notch signaling pathway, but its role in breast cancer (BC) remains unclear. In this research, JAG1 protein expression in BC tissues was detected by immunohistochemistry. The association between JAG1 and clinical...

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Autores principales: Qiao, Xiaojuan, Ma, Buhuan, Sun, Weiting, Zhang, Ning, Liu, Yang, Jia, Lizhou, Liu, Caixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768120/
https://www.ncbi.nlm.nih.gov/pubmed/36539520
http://dx.doi.org/10.1038/s41598-022-26241-8
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author Qiao, Xiaojuan
Ma, Buhuan
Sun, Weiting
Zhang, Ning
Liu, Yang
Jia, Lizhou
Liu, Caixia
author_facet Qiao, Xiaojuan
Ma, Buhuan
Sun, Weiting
Zhang, Ning
Liu, Yang
Jia, Lizhou
Liu, Caixia
author_sort Qiao, Xiaojuan
collection PubMed
description Jagged canonical Notch ligand 1 (JAG1) regulates the progression of many cancers by the Notch signaling pathway, but its role in breast cancer (BC) remains unclear. In this research, JAG1 protein expression in BC tissues was detected by immunohistochemistry. The association between JAG1 and clinical significance was analyzed. The effect of JAG1 on malignant behaviors of BC cells was demonstrated by in vitro experiments. JAG1 expression in BC tissues was higher than that in para-carcinoma tissues. High JAG1 expression was significantly linked to advanced lymph node metastasis, distant metastasis, and the TNM stage. JAG1 was an independent prognostic factor for BC patients. JAG1 knockdown inhibited the proliferation, motility, migration, and invasion of BC cells, and weakened adhesion and penetration abilities to the blood–brain barrier, whereas JAG1 overexpression had the opposite effects. JAG1 has the potential to be a prognostic marker and therapeutic target for BC patients.
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spelling pubmed-97681202022-12-22 JAG1 is associated with the prognosis and metastasis in breast cancer Qiao, Xiaojuan Ma, Buhuan Sun, Weiting Zhang, Ning Liu, Yang Jia, Lizhou Liu, Caixia Sci Rep Article Jagged canonical Notch ligand 1 (JAG1) regulates the progression of many cancers by the Notch signaling pathway, but its role in breast cancer (BC) remains unclear. In this research, JAG1 protein expression in BC tissues was detected by immunohistochemistry. The association between JAG1 and clinical significance was analyzed. The effect of JAG1 on malignant behaviors of BC cells was demonstrated by in vitro experiments. JAG1 expression in BC tissues was higher than that in para-carcinoma tissues. High JAG1 expression was significantly linked to advanced lymph node metastasis, distant metastasis, and the TNM stage. JAG1 was an independent prognostic factor for BC patients. JAG1 knockdown inhibited the proliferation, motility, migration, and invasion of BC cells, and weakened adhesion and penetration abilities to the blood–brain barrier, whereas JAG1 overexpression had the opposite effects. JAG1 has the potential to be a prognostic marker and therapeutic target for BC patients. Nature Publishing Group UK 2022-12-20 /pmc/articles/PMC9768120/ /pubmed/36539520 http://dx.doi.org/10.1038/s41598-022-26241-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Qiao, Xiaojuan
Ma, Buhuan
Sun, Weiting
Zhang, Ning
Liu, Yang
Jia, Lizhou
Liu, Caixia
JAG1 is associated with the prognosis and metastasis in breast cancer
title JAG1 is associated with the prognosis and metastasis in breast cancer
title_full JAG1 is associated with the prognosis and metastasis in breast cancer
title_fullStr JAG1 is associated with the prognosis and metastasis in breast cancer
title_full_unstemmed JAG1 is associated with the prognosis and metastasis in breast cancer
title_short JAG1 is associated with the prognosis and metastasis in breast cancer
title_sort jag1 is associated with the prognosis and metastasis in breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768120/
https://www.ncbi.nlm.nih.gov/pubmed/36539520
http://dx.doi.org/10.1038/s41598-022-26241-8
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