Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis

Persistent Nrf2 activation is typically noted in many cancers, including colorectal cancer (CRC), aiding cancer cells in overcoming growth stress and promoting cancer progression. Sustained Nrf2 activation, which is beneficial for cancer cells, is called “Nrf2 addiction”; it is closely associated wi...

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Detalles Bibliográficos
Autores principales: Hsu, Wei-Lun, Wang, Chieh-Min, Yao, Chao-Ling, Chen, Ssu-Ching, Nien, Chung-Yi, Sun, Yang-Ho, Tseng, Tsung-Yu, Luo, Yueh-Hsia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768144/
https://www.ncbi.nlm.nih.gov/pubmed/36539411
http://dx.doi.org/10.1038/s41419-022-05512-2

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