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Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY

The development of new antibacterial drugs with different mechanisms of action is urgently needed to address antimicrobial resistance. MraY is an essential membrane enzyme required for bacterial cell wall synthesis. Sphaerimicins are naturally occurring macrocyclic nucleoside inhibitors of MraY and...

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Detalles Bibliográficos
Autores principales:	Nakaya, Takeshi, Yabe, Miyuki, Mashalidis, Ellene H., Sato, Toyotaka, Yamamoto, Kazuki, Hikiji, Yuta, Katsuyama, Akira, Shinohara, Motoko, Minato, Yusuke, Takahashi, Satoshi, Horiuchi, Motohiro, Yokota, Shin-ichi, Lee, Seok-Yong, Ichikawa, Satoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768162/ https://www.ncbi.nlm.nih.gov/pubmed/36539416 http://dx.doi.org/10.1038/s41467-022-35227-z

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