Pharmacological targeting of the mitochondrial calcium-dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivo

Ion channels are non-conventional, druggable oncological targets. The intermediate-conductance calcium-dependent potassium channel (K(Ca)3.1) is highly expressed in the plasma membrane and in the inner mitochondrial membrane (mitoK(Ca)3.1) of various cancer cell lines. The role mitoK(Ca)3.1 plays in...

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Detalles Bibliográficos
Autores principales: Bachmann, Magdalena, Rossa, Andrea, Varanita, Tatiana, Fioretti, Bernard, Biasutto, Lucia, Milenkovic, Stefan, Checchetto, Vanessa, Peruzzo, Roberta, Ahmad, Syed A., Patel, Sameer H., Lukowski, Robert, Edwards, Michael J., Ceccarelli, Matteo, Gulbins, Erich, Zoratti, Mario, Mattarei, Andrea, Szabo, Ildiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768205/
https://www.ncbi.nlm.nih.gov/pubmed/36539400
http://dx.doi.org/10.1038/s41419-022-05463-8

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