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Increased CCR4+ and Decreased Central Memory CD4+ T Lymphocytes in the Background Gastric Mucosa of Patients Developing Gastric Cancer After Helicobacter pylori Eradication: An Exploratory Study

The composition of lymphocytes in the gastric mucosa following the eradication of Helicobacter pylori (H. pylori) in patients with and without gastric cancer has not been compared. This study performed a single spot analysis of gastric mucosal lymphocytes after H. pylori eradication in patients with...

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Autores principales: Iwamuro, Masaya, Takahashi, Takahide, Hirabata, Araki, Tanaka, Takehiro, Otsuka, Fumio, Okada, Horoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768248/
https://www.ncbi.nlm.nih.gov/pubmed/36569708
http://dx.doi.org/10.7759/cureus.31713
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author Iwamuro, Masaya
Takahashi, Takahide
Hirabata, Araki
Tanaka, Takehiro
Otsuka, Fumio
Okada, Horoyuki
author_facet Iwamuro, Masaya
Takahashi, Takahide
Hirabata, Araki
Tanaka, Takehiro
Otsuka, Fumio
Okada, Horoyuki
author_sort Iwamuro, Masaya
collection PubMed
description The composition of lymphocytes in the gastric mucosa following the eradication of Helicobacter pylori (H. pylori) in patients with and without gastric cancer has not been compared. This study performed a single spot analysis of gastric mucosal lymphocytes after H. pylori eradication in patients with (n = 13) and without (n = 20) gastric cancer. Our comprehensive analysis of lymphocyte composition in the gastric mucosa revealed that: i) the proportion of CD8(+)/CD3(+) cells was relatively higher in the peri-tumor mucosa than in the background mucosa; ii) the proportion of CCR4(+)/CD3(+) cells was higher, and the ratio of CD62L(+)/CD3(+)CD4(+) cells was relatively lower in the gastric mucosa of cancer patients than in non-cancer patients; and iii) the proportion of CD45RA(−)CD62L(+)/CD3(+)CD4(+) cells, namely, the central memory CD4(+) T-cell fraction, was lower in the gastric mucosa of cancer patients than in non-cancer patients. Although the exact mechanism of the altered proportions of CCR4(+)/CD3(+) and central memory CD4(+) cells in the gastric mucosa of patients with cancer is unknown, focusing on lymphocytes in the gastric mucosa might help improve our understanding of gastric cancer development after H. pylori eradication.
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spelling pubmed-97682482022-12-22 Increased CCR4+ and Decreased Central Memory CD4+ T Lymphocytes in the Background Gastric Mucosa of Patients Developing Gastric Cancer After Helicobacter pylori Eradication: An Exploratory Study Iwamuro, Masaya Takahashi, Takahide Hirabata, Araki Tanaka, Takehiro Otsuka, Fumio Okada, Horoyuki Cureus Gastroenterology The composition of lymphocytes in the gastric mucosa following the eradication of Helicobacter pylori (H. pylori) in patients with and without gastric cancer has not been compared. This study performed a single spot analysis of gastric mucosal lymphocytes after H. pylori eradication in patients with (n = 13) and without (n = 20) gastric cancer. Our comprehensive analysis of lymphocyte composition in the gastric mucosa revealed that: i) the proportion of CD8(+)/CD3(+) cells was relatively higher in the peri-tumor mucosa than in the background mucosa; ii) the proportion of CCR4(+)/CD3(+) cells was higher, and the ratio of CD62L(+)/CD3(+)CD4(+) cells was relatively lower in the gastric mucosa of cancer patients than in non-cancer patients; and iii) the proportion of CD45RA(−)CD62L(+)/CD3(+)CD4(+) cells, namely, the central memory CD4(+) T-cell fraction, was lower in the gastric mucosa of cancer patients than in non-cancer patients. Although the exact mechanism of the altered proportions of CCR4(+)/CD3(+) and central memory CD4(+) cells in the gastric mucosa of patients with cancer is unknown, focusing on lymphocytes in the gastric mucosa might help improve our understanding of gastric cancer development after H. pylori eradication. Cureus 2022-11-20 /pmc/articles/PMC9768248/ /pubmed/36569708 http://dx.doi.org/10.7759/cureus.31713 Text en Copyright © 2022, Iwamuro et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Gastroenterology
Iwamuro, Masaya
Takahashi, Takahide
Hirabata, Araki
Tanaka, Takehiro
Otsuka, Fumio
Okada, Horoyuki
Increased CCR4+ and Decreased Central Memory CD4+ T Lymphocytes in the Background Gastric Mucosa of Patients Developing Gastric Cancer After Helicobacter pylori Eradication: An Exploratory Study
title Increased CCR4+ and Decreased Central Memory CD4+ T Lymphocytes in the Background Gastric Mucosa of Patients Developing Gastric Cancer After Helicobacter pylori Eradication: An Exploratory Study
title_full Increased CCR4+ and Decreased Central Memory CD4+ T Lymphocytes in the Background Gastric Mucosa of Patients Developing Gastric Cancer After Helicobacter pylori Eradication: An Exploratory Study
title_fullStr Increased CCR4+ and Decreased Central Memory CD4+ T Lymphocytes in the Background Gastric Mucosa of Patients Developing Gastric Cancer After Helicobacter pylori Eradication: An Exploratory Study
title_full_unstemmed Increased CCR4+ and Decreased Central Memory CD4+ T Lymphocytes in the Background Gastric Mucosa of Patients Developing Gastric Cancer After Helicobacter pylori Eradication: An Exploratory Study
title_short Increased CCR4+ and Decreased Central Memory CD4+ T Lymphocytes in the Background Gastric Mucosa of Patients Developing Gastric Cancer After Helicobacter pylori Eradication: An Exploratory Study
title_sort increased ccr4+ and decreased central memory cd4+ t lymphocytes in the background gastric mucosa of patients developing gastric cancer after helicobacter pylori eradication: an exploratory study
topic Gastroenterology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768248/
https://www.ncbi.nlm.nih.gov/pubmed/36569708
http://dx.doi.org/10.7759/cureus.31713
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