Orai1 overexpression improves sepsis-induced T-lymphocyte immunosuppression and acute organ dysfunction in mice

Immune paralysis induced by sepsis, especially dysfunction of CD4(+) T cells, leads to an increased risk of infection. In sepsis, abnormal differentiation of T lymphocytes is associated with multiorgan dysfunction syndrome. In T lymphocytes, the Orai1/nuclear factor of activated T Cells (NFAT) pathw...

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Detalles Bibliográficos
Autores principales: Chen, Longwang, Ke, Heliang, Zhang, Yaolu, Jin, Pinpin, Liu, Xinyong, Hong, Guangliang, Zhao, Guangju, Lu, Zhongqiu, Wu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768300/
https://www.ncbi.nlm.nih.gov/pubmed/36568656
http://dx.doi.org/10.1016/j.heliyon.2022.e12082

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