Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation

The LAT transmembrane adaptor is essential to transduce intracellular signals triggered by the TCR. Phosphorylation of its four C-terminal tyrosine residues (136, 175, 195, and 235 in mouse LAT) recruits several proteins resulting in the assembly of the LAT signalosome. Among those tyrosine residues...

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Detalles Bibliográficos
Autores principales: Arbulo-Echevarria, Mikel M., Vico-Barranco, Inmaculada, Zhang, Fanghui, Fernandez-Aguilar, Luis M., Chotomska, Martyna, Narbona-Sánchez, Isaac, Zhang, Lichen, Malissen, Bernard, Liang, Yinming, Aguado, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768323/
https://www.ncbi.nlm.nih.gov/pubmed/36569841
http://dx.doi.org/10.3389/fimmu.2022.1054920

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