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A tailored passive driver for liver MRE in pediatric patients

OBJECTIVES: Magnetic resonance elastography (MRE) is increasingly used in the pediatric population for diagnosis and staging of liver fibrosis. However, the MR-compatible driver and sequences are usually those used for adult patients. Our feasibility study aimed to adapt the standardized adult MRE p...

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Autores principales: Lorton, Orane, Toso, Seema, El-Begri Talbi, Hayat, Anooshiravani, Mehrak, Poletti, Pierre-Alexandre, Hanquinet, Sylviane, Salomir, Rares
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768363/
https://www.ncbi.nlm.nih.gov/pubmed/36568430
http://dx.doi.org/10.3389/fped.2022.999830
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author Lorton, Orane
Toso, Seema
El-Begri Talbi, Hayat
Anooshiravani, Mehrak
Poletti, Pierre-Alexandre
Hanquinet, Sylviane
Salomir, Rares
author_facet Lorton, Orane
Toso, Seema
El-Begri Talbi, Hayat
Anooshiravani, Mehrak
Poletti, Pierre-Alexandre
Hanquinet, Sylviane
Salomir, Rares
author_sort Lorton, Orane
collection PubMed
description OBJECTIVES: Magnetic resonance elastography (MRE) is increasingly used in the pediatric population for diagnosis and staging of liver fibrosis. However, the MR-compatible driver and sequences are usually those used for adult patients. Our feasibility study aimed to adapt the standardized adult MRE passive driver and vibrational parameters to a pediatric population. METHODS: We designed an elliptic passive driver shaped on a torus equipped with an elastic membrane and adapted to children's morphologies. As a first step, eight children (aged 8–18 years) were enrolled in a prospective pilot study aiming to determine the threshold vibrational amplitude for MRE using a custom passive driver, based on phase aliasing assessment and the occurrence of signal void artifacts on magnitude MR images. In the second step, the practicality and the consistency of the custom driver were assessed in a further 11 pediatric patients (aged 7–18 years). In the third step, we compared our custom driver vs. the commercial driver on six adult volunteers, in terms of the reliable region of interest area within the acquired MRE slices, the shear wave maps’ quality, and measured stiffness values obtained. RESULTS: Based on pediatric patient data, the threshold vibrational amplitude expressed as percentage of maximum output was found to be 0.4 and 1.1 times the body weight (kg) at 40 and 60 Hz frequencies, respectively. In comparison to the commercial passive driver, the custom driver improved threefold the contact with the body surface, also enabling a more comfortable examination as self-assessed by the volunteers. CONCLUSIONS: Our custom driver was more comfortable for the volunteers and was able to generate more homogenous shear waves, yielding larger usable hepatic area, and more reliable stiffness values.
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spelling pubmed-97683632022-12-22 A tailored passive driver for liver MRE in pediatric patients Lorton, Orane Toso, Seema El-Begri Talbi, Hayat Anooshiravani, Mehrak Poletti, Pierre-Alexandre Hanquinet, Sylviane Salomir, Rares Front Pediatr Pediatrics OBJECTIVES: Magnetic resonance elastography (MRE) is increasingly used in the pediatric population for diagnosis and staging of liver fibrosis. However, the MR-compatible driver and sequences are usually those used for adult patients. Our feasibility study aimed to adapt the standardized adult MRE passive driver and vibrational parameters to a pediatric population. METHODS: We designed an elliptic passive driver shaped on a torus equipped with an elastic membrane and adapted to children's morphologies. As a first step, eight children (aged 8–18 years) were enrolled in a prospective pilot study aiming to determine the threshold vibrational amplitude for MRE using a custom passive driver, based on phase aliasing assessment and the occurrence of signal void artifacts on magnitude MR images. In the second step, the practicality and the consistency of the custom driver were assessed in a further 11 pediatric patients (aged 7–18 years). In the third step, we compared our custom driver vs. the commercial driver on six adult volunteers, in terms of the reliable region of interest area within the acquired MRE slices, the shear wave maps’ quality, and measured stiffness values obtained. RESULTS: Based on pediatric patient data, the threshold vibrational amplitude expressed as percentage of maximum output was found to be 0.4 and 1.1 times the body weight (kg) at 40 and 60 Hz frequencies, respectively. In comparison to the commercial passive driver, the custom driver improved threefold the contact with the body surface, also enabling a more comfortable examination as self-assessed by the volunteers. CONCLUSIONS: Our custom driver was more comfortable for the volunteers and was able to generate more homogenous shear waves, yielding larger usable hepatic area, and more reliable stiffness values. Frontiers Media S.A. 2022-12-07 /pmc/articles/PMC9768363/ /pubmed/36568430 http://dx.doi.org/10.3389/fped.2022.999830 Text en © 2022 Lorton, Toso, El-Begri Talbi, Anooshiravani, Poletti, Hanquinet and Salomir. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Lorton, Orane
Toso, Seema
El-Begri Talbi, Hayat
Anooshiravani, Mehrak
Poletti, Pierre-Alexandre
Hanquinet, Sylviane
Salomir, Rares
A tailored passive driver for liver MRE in pediatric patients
title A tailored passive driver for liver MRE in pediatric patients
title_full A tailored passive driver for liver MRE in pediatric patients
title_fullStr A tailored passive driver for liver MRE in pediatric patients
title_full_unstemmed A tailored passive driver for liver MRE in pediatric patients
title_short A tailored passive driver for liver MRE in pediatric patients
title_sort tailored passive driver for liver mre in pediatric patients
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768363/
https://www.ncbi.nlm.nih.gov/pubmed/36568430
http://dx.doi.org/10.3389/fped.2022.999830
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