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Engineering exosomes for bone defect repair

Currently, bone defect repair is still an intractable clinical problem. Numerous treatments have been performed, but their clinical results are unsatisfactory. As a key element of cell-free therapy, exosome is becoming a promising tool of bone regeneration in recent decades, because of its promoting...

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Detalles Bibliográficos
Autores principales: Ma, Shaoyang, Zhang, Yuchen, Li, Sijia, Li, Ang, Li, Ye, Pei, Dandan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768454/
https://www.ncbi.nlm.nih.gov/pubmed/36568296
http://dx.doi.org/10.3389/fbioe.2022.1091360
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author Ma, Shaoyang
Zhang, Yuchen
Li, Sijia
Li, Ang
Li, Ye
Pei, Dandan
author_facet Ma, Shaoyang
Zhang, Yuchen
Li, Sijia
Li, Ang
Li, Ye
Pei, Dandan
author_sort Ma, Shaoyang
collection PubMed
description Currently, bone defect repair is still an intractable clinical problem. Numerous treatments have been performed, but their clinical results are unsatisfactory. As a key element of cell-free therapy, exosome is becoming a promising tool of bone regeneration in recent decades, because of its promoting osteogenesis and osteogenic differentiation function in vivo and in vitro. However, low yield, weak activity, inefficient targeting ability, and unpredictable side effects of natural exosomes have limited the clinical application. To overcome the weakness, various approaches have been applied to produce engineering exosomes by regulating their production and function at present. In this review, we will focus on the engineering exosomes for bone defect repair. By summarizing the exosomal cargos affecting osteogenesis, the strategies of engineering exosomes and properties of exosome-integrated biomaterials, this work will provide novel insights into exploring advanced engineering exosome-based cell-free therapy for bone defect repair.
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spelling pubmed-97684542022-12-22 Engineering exosomes for bone defect repair Ma, Shaoyang Zhang, Yuchen Li, Sijia Li, Ang Li, Ye Pei, Dandan Front Bioeng Biotechnol Bioengineering and Biotechnology Currently, bone defect repair is still an intractable clinical problem. Numerous treatments have been performed, but their clinical results are unsatisfactory. As a key element of cell-free therapy, exosome is becoming a promising tool of bone regeneration in recent decades, because of its promoting osteogenesis and osteogenic differentiation function in vivo and in vitro. However, low yield, weak activity, inefficient targeting ability, and unpredictable side effects of natural exosomes have limited the clinical application. To overcome the weakness, various approaches have been applied to produce engineering exosomes by regulating their production and function at present. In this review, we will focus on the engineering exosomes for bone defect repair. By summarizing the exosomal cargos affecting osteogenesis, the strategies of engineering exosomes and properties of exosome-integrated biomaterials, this work will provide novel insights into exploring advanced engineering exosome-based cell-free therapy for bone defect repair. Frontiers Media S.A. 2022-12-07 /pmc/articles/PMC9768454/ /pubmed/36568296 http://dx.doi.org/10.3389/fbioe.2022.1091360 Text en Copyright © 2022 Ma, Zhang, Li, Li, Li and Pei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Ma, Shaoyang
Zhang, Yuchen
Li, Sijia
Li, Ang
Li, Ye
Pei, Dandan
Engineering exosomes for bone defect repair
title Engineering exosomes for bone defect repair
title_full Engineering exosomes for bone defect repair
title_fullStr Engineering exosomes for bone defect repair
title_full_unstemmed Engineering exosomes for bone defect repair
title_short Engineering exosomes for bone defect repair
title_sort engineering exosomes for bone defect repair
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768454/
https://www.ncbi.nlm.nih.gov/pubmed/36568296
http://dx.doi.org/10.3389/fbioe.2022.1091360
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