Cargando…
Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the Coronaviridae and Togaviridae families (Review)
Outbreaks of zoonotic viral diseases pose a severe threat to public health and economies worldwide, with this currently being more prominent than it previously was human history. These emergency zoonotic diseases that originated and transmitted from vertebrates to humans have been estimated to accou...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768462/ https://www.ncbi.nlm.nih.gov/pubmed/36569444 http://dx.doi.org/10.3892/etm.2022.11741 |
_version_ | 1784854173282467840 |
---|---|
author | Babaeimarzangou, Seyed Sajjad Zaker, Himasadat Soleimannezhadbari, Ehsan Gamchi, Naeimeh Shamsi Kazeminia, Masoud Tarighi, Shima Seyedian, Homayon Tsatsakis, Aristidis Spandidos, Demetrios A. Margina, Denisa |
author_facet | Babaeimarzangou, Seyed Sajjad Zaker, Himasadat Soleimannezhadbari, Ehsan Gamchi, Naeimeh Shamsi Kazeminia, Masoud Tarighi, Shima Seyedian, Homayon Tsatsakis, Aristidis Spandidos, Demetrios A. Margina, Denisa |
author_sort | Babaeimarzangou, Seyed Sajjad |
collection | PubMed |
description | Outbreaks of zoonotic viral diseases pose a severe threat to public health and economies worldwide, with this currently being more prominent than it previously was human history. These emergency zoonotic diseases that originated and transmitted from vertebrates to humans have been estimated to account for approximately one billion cases of illness and have caused millions of deaths worldwide annually. The recent emergence of severe acute respiratory syndrome coronavirus-2 (coronavirus disease 2019) is an excellent example of the unpredictable public health threat causing a pandemic. The present review summarizes the literature data regarding the main vaccine developments in human clinical phase I, II and III trials against the zoonotic positive-sense single-stranded RNA viruses belonging to the Coronavirus and Alphavirus genera, including severe acute respiratory syndrome, Middle east respiratory syndrome, Venezuelan equine encephalitis virus, Semliki Forest virus, Ross River virus, Chikungunya virus and O'nyong-nyong virus. That there are neither vaccines nor effective antiviral drugs available against most of these viruses is undeniable. Therefore, new explosive outbreaks of these zoonotic viruses may surely be expected. The present comprehensive review provides an update on the status of vaccine development in different clinical trials against these viruses, as well as an overview of the present results of these trials. |
format | Online Article Text |
id | pubmed-9768462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-97684622022-12-22 Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the Coronaviridae and Togaviridae families (Review) Babaeimarzangou, Seyed Sajjad Zaker, Himasadat Soleimannezhadbari, Ehsan Gamchi, Naeimeh Shamsi Kazeminia, Masoud Tarighi, Shima Seyedian, Homayon Tsatsakis, Aristidis Spandidos, Demetrios A. Margina, Denisa Exp Ther Med Review Outbreaks of zoonotic viral diseases pose a severe threat to public health and economies worldwide, with this currently being more prominent than it previously was human history. These emergency zoonotic diseases that originated and transmitted from vertebrates to humans have been estimated to account for approximately one billion cases of illness and have caused millions of deaths worldwide annually. The recent emergence of severe acute respiratory syndrome coronavirus-2 (coronavirus disease 2019) is an excellent example of the unpredictable public health threat causing a pandemic. The present review summarizes the literature data regarding the main vaccine developments in human clinical phase I, II and III trials against the zoonotic positive-sense single-stranded RNA viruses belonging to the Coronavirus and Alphavirus genera, including severe acute respiratory syndrome, Middle east respiratory syndrome, Venezuelan equine encephalitis virus, Semliki Forest virus, Ross River virus, Chikungunya virus and O'nyong-nyong virus. That there are neither vaccines nor effective antiviral drugs available against most of these viruses is undeniable. Therefore, new explosive outbreaks of these zoonotic viruses may surely be expected. The present comprehensive review provides an update on the status of vaccine development in different clinical trials against these viruses, as well as an overview of the present results of these trials. D.A. Spandidos 2022-11-30 /pmc/articles/PMC9768462/ /pubmed/36569444 http://dx.doi.org/10.3892/etm.2022.11741 Text en Copyright: © Babaeimarzangou et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Babaeimarzangou, Seyed Sajjad Zaker, Himasadat Soleimannezhadbari, Ehsan Gamchi, Naeimeh Shamsi Kazeminia, Masoud Tarighi, Shima Seyedian, Homayon Tsatsakis, Aristidis Spandidos, Demetrios A. Margina, Denisa Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the Coronaviridae and Togaviridae families (Review) |
title | Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the Coronaviridae and Togaviridae families (Review) |
title_full | Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the Coronaviridae and Togaviridae families (Review) |
title_fullStr | Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the Coronaviridae and Togaviridae families (Review) |
title_full_unstemmed | Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the Coronaviridae and Togaviridae families (Review) |
title_short | Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the Coronaviridae and Togaviridae families (Review) |
title_sort | vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded rna viruses belonging to the coronaviridae and togaviridae families (review) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768462/ https://www.ncbi.nlm.nih.gov/pubmed/36569444 http://dx.doi.org/10.3892/etm.2022.11741 |
work_keys_str_mv | AT babaeimarzangouseyedsajjad vaccinedevelopmentforzoonoticviraldiseasescausedbypositivesensesinglestrandedrnavirusesbelongingtothecoronaviridaeandtogaviridaefamiliesreview AT zakerhimasadat vaccinedevelopmentforzoonoticviraldiseasescausedbypositivesensesinglestrandedrnavirusesbelongingtothecoronaviridaeandtogaviridaefamiliesreview AT soleimannezhadbariehsan vaccinedevelopmentforzoonoticviraldiseasescausedbypositivesensesinglestrandedrnavirusesbelongingtothecoronaviridaeandtogaviridaefamiliesreview AT gamchinaeimehshamsi vaccinedevelopmentforzoonoticviraldiseasescausedbypositivesensesinglestrandedrnavirusesbelongingtothecoronaviridaeandtogaviridaefamiliesreview AT kazeminiamasoud vaccinedevelopmentforzoonoticviraldiseasescausedbypositivesensesinglestrandedrnavirusesbelongingtothecoronaviridaeandtogaviridaefamiliesreview AT tarighishima vaccinedevelopmentforzoonoticviraldiseasescausedbypositivesensesinglestrandedrnavirusesbelongingtothecoronaviridaeandtogaviridaefamiliesreview AT seyedianhomayon vaccinedevelopmentforzoonoticviraldiseasescausedbypositivesensesinglestrandedrnavirusesbelongingtothecoronaviridaeandtogaviridaefamiliesreview AT tsatsakisaristidis vaccinedevelopmentforzoonoticviraldiseasescausedbypositivesensesinglestrandedrnavirusesbelongingtothecoronaviridaeandtogaviridaefamiliesreview AT spandidosdemetriosa vaccinedevelopmentforzoonoticviraldiseasescausedbypositivesensesinglestrandedrnavirusesbelongingtothecoronaviridaeandtogaviridaefamiliesreview AT marginadenisa vaccinedevelopmentforzoonoticviraldiseasescausedbypositivesensesinglestrandedrnavirusesbelongingtothecoronaviridaeandtogaviridaefamiliesreview |