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Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the Coronaviridae and Togaviridae families (Review)

Outbreaks of zoonotic viral diseases pose a severe threat to public health and economies worldwide, with this currently being more prominent than it previously was human history. These emergency zoonotic diseases that originated and transmitted from vertebrates to humans have been estimated to accou...

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Autores principales: Babaeimarzangou, Seyed Sajjad, Zaker, Himasadat, Soleimannezhadbari, Ehsan, Gamchi, Naeimeh Shamsi, Kazeminia, Masoud, Tarighi, Shima, Seyedian, Homayon, Tsatsakis, Aristidis, Spandidos, Demetrios A., Margina, Denisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768462/
https://www.ncbi.nlm.nih.gov/pubmed/36569444
http://dx.doi.org/10.3892/etm.2022.11741
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author Babaeimarzangou, Seyed Sajjad
Zaker, Himasadat
Soleimannezhadbari, Ehsan
Gamchi, Naeimeh Shamsi
Kazeminia, Masoud
Tarighi, Shima
Seyedian, Homayon
Tsatsakis, Aristidis
Spandidos, Demetrios A.
Margina, Denisa
author_facet Babaeimarzangou, Seyed Sajjad
Zaker, Himasadat
Soleimannezhadbari, Ehsan
Gamchi, Naeimeh Shamsi
Kazeminia, Masoud
Tarighi, Shima
Seyedian, Homayon
Tsatsakis, Aristidis
Spandidos, Demetrios A.
Margina, Denisa
author_sort Babaeimarzangou, Seyed Sajjad
collection PubMed
description Outbreaks of zoonotic viral diseases pose a severe threat to public health and economies worldwide, with this currently being more prominent than it previously was human history. These emergency zoonotic diseases that originated and transmitted from vertebrates to humans have been estimated to account for approximately one billion cases of illness and have caused millions of deaths worldwide annually. The recent emergence of severe acute respiratory syndrome coronavirus-2 (coronavirus disease 2019) is an excellent example of the unpredictable public health threat causing a pandemic. The present review summarizes the literature data regarding the main vaccine developments in human clinical phase I, II and III trials against the zoonotic positive-sense single-stranded RNA viruses belonging to the Coronavirus and Alphavirus genera, including severe acute respiratory syndrome, Middle east respiratory syndrome, Venezuelan equine encephalitis virus, Semliki Forest virus, Ross River virus, Chikungunya virus and O'nyong-nyong virus. That there are neither vaccines nor effective antiviral drugs available against most of these viruses is undeniable. Therefore, new explosive outbreaks of these zoonotic viruses may surely be expected. The present comprehensive review provides an update on the status of vaccine development in different clinical trials against these viruses, as well as an overview of the present results of these trials.
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spelling pubmed-97684622022-12-22 Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the Coronaviridae and Togaviridae families (Review) Babaeimarzangou, Seyed Sajjad Zaker, Himasadat Soleimannezhadbari, Ehsan Gamchi, Naeimeh Shamsi Kazeminia, Masoud Tarighi, Shima Seyedian, Homayon Tsatsakis, Aristidis Spandidos, Demetrios A. Margina, Denisa Exp Ther Med Review Outbreaks of zoonotic viral diseases pose a severe threat to public health and economies worldwide, with this currently being more prominent than it previously was human history. These emergency zoonotic diseases that originated and transmitted from vertebrates to humans have been estimated to account for approximately one billion cases of illness and have caused millions of deaths worldwide annually. The recent emergence of severe acute respiratory syndrome coronavirus-2 (coronavirus disease 2019) is an excellent example of the unpredictable public health threat causing a pandemic. The present review summarizes the literature data regarding the main vaccine developments in human clinical phase I, II and III trials against the zoonotic positive-sense single-stranded RNA viruses belonging to the Coronavirus and Alphavirus genera, including severe acute respiratory syndrome, Middle east respiratory syndrome, Venezuelan equine encephalitis virus, Semliki Forest virus, Ross River virus, Chikungunya virus and O'nyong-nyong virus. That there are neither vaccines nor effective antiviral drugs available against most of these viruses is undeniable. Therefore, new explosive outbreaks of these zoonotic viruses may surely be expected. The present comprehensive review provides an update on the status of vaccine development in different clinical trials against these viruses, as well as an overview of the present results of these trials. D.A. Spandidos 2022-11-30 /pmc/articles/PMC9768462/ /pubmed/36569444 http://dx.doi.org/10.3892/etm.2022.11741 Text en Copyright: © Babaeimarzangou et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Babaeimarzangou, Seyed Sajjad
Zaker, Himasadat
Soleimannezhadbari, Ehsan
Gamchi, Naeimeh Shamsi
Kazeminia, Masoud
Tarighi, Shima
Seyedian, Homayon
Tsatsakis, Aristidis
Spandidos, Demetrios A.
Margina, Denisa
Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the Coronaviridae and Togaviridae families (Review)
title Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the Coronaviridae and Togaviridae families (Review)
title_full Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the Coronaviridae and Togaviridae families (Review)
title_fullStr Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the Coronaviridae and Togaviridae families (Review)
title_full_unstemmed Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the Coronaviridae and Togaviridae families (Review)
title_short Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the Coronaviridae and Togaviridae families (Review)
title_sort vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded rna viruses belonging to the coronaviridae and togaviridae families (review)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768462/
https://www.ncbi.nlm.nih.gov/pubmed/36569444
http://dx.doi.org/10.3892/etm.2022.11741
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