Quantification of the hydride donor abilities of NADH, NADPH, and BH(3)CN(−) in water

The nucleophilic reactivities of the hydride donors NADH, NADPH, and BH(3)CN(−) in water were quantified using kinetic measurements with benzhydrylium ions as reference electrophiles. All three hydride donors were found to possess almost identical nucleophilic reactivities, providing a potential exp...

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Detalles Bibliográficos
Autores principales: Mayer, Robert J., Moran, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768570/
https://www.ncbi.nlm.nih.gov/pubmed/36472236
http://dx.doi.org/10.1039/d2ob02041f
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author Mayer, Robert J.
Moran, Joseph
author_facet Mayer, Robert J.
Moran, Joseph
author_sort Mayer, Robert J.
collection PubMed
description The nucleophilic reactivities of the hydride donors NADH, NADPH, and BH(3)CN(−) in water were quantified using kinetic measurements with benzhydrylium ions as reference electrophiles. All three hydride donors were found to possess almost identical nucleophilic reactivities, providing a potential explanation for why they are involved in similar transformations in biochemistry and organic synthesis, respectively.
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spelling pubmed-97685702023-01-04 Quantification of the hydride donor abilities of NADH, NADPH, and BH(3)CN(−) in water Mayer, Robert J. Moran, Joseph Org Biomol Chem Chemistry The nucleophilic reactivities of the hydride donors NADH, NADPH, and BH(3)CN(−) in water were quantified using kinetic measurements with benzhydrylium ions as reference electrophiles. All three hydride donors were found to possess almost identical nucleophilic reactivities, providing a potential explanation for why they are involved in similar transformations in biochemistry and organic synthesis, respectively. The Royal Society of Chemistry 2022-12-06 /pmc/articles/PMC9768570/ /pubmed/36472236 http://dx.doi.org/10.1039/d2ob02041f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Mayer, Robert J.
Moran, Joseph
Quantification of the hydride donor abilities of NADH, NADPH, and BH(3)CN(−) in water
title Quantification of the hydride donor abilities of NADH, NADPH, and BH(3)CN(−) in water
title_full Quantification of the hydride donor abilities of NADH, NADPH, and BH(3)CN(−) in water
title_fullStr Quantification of the hydride donor abilities of NADH, NADPH, and BH(3)CN(−) in water
title_full_unstemmed Quantification of the hydride donor abilities of NADH, NADPH, and BH(3)CN(−) in water
title_short Quantification of the hydride donor abilities of NADH, NADPH, and BH(3)CN(−) in water
title_sort quantification of the hydride donor abilities of nadh, nadph, and bh(3)cn(−) in water
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768570/
https://www.ncbi.nlm.nih.gov/pubmed/36472236
http://dx.doi.org/10.1039/d2ob02041f
work_keys_str_mv AT mayerrobertj quantificationofthehydridedonorabilitiesofnadhnadphandbh3cninwater
AT moranjoseph quantificationofthehydridedonorabilitiesofnadhnadphandbh3cninwater

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