Loss of mismatch repair promotes a direct selective advantage in human stem cells

Lynch syndrome (LS) is the most common hereditary form of colon cancer, resulting from a germline mutation in a DNA mismatch repair (MMR) gene. Loss of MMR in cells establishes a mutator phenotype, which may underlie its link to cancer. Acquired downstream mutations that provide the cell a selective...

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Detalles Bibliográficos
Autores principales: Madden-Hennessey, Kirby, Gupta, Dipika, Radecki, Alexander A., Guild, Caroline, Rath, Abhijit, Heinen, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768573/
https://www.ncbi.nlm.nih.gov/pubmed/36368329
http://dx.doi.org/10.1016/j.stemcr.2022.10.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768573/
https://www.ncbi.nlm.nih.gov/pubmed/36368329
http://dx.doi.org/10.1016/j.stemcr.2022.10.009

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