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Directly induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplantation in vivo

Retinal ganglion cell (RGC) replacement therapy could restore vision in glaucoma and other optic neuropathies. We developed a rapid protocol for directly induced RGC (iRGC) differentiation from human stem cells, leveraging overexpression of NGN2. Neuronal morphology and neurite growth were observed...

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Detalles Bibliográficos
Autores principales:	Luo, Ziming, Chang, Kun-Che, Wu, Suqian, Sun, Catalina, Xia, Xin, Nahmou, Michael, Bian, Minjuan, Wen, Rain R., Zhu, Ying, Shah, Sahil, Tanasa, Bogdan, Wernig, Marius, Goldberg, Jeffrey L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768574/ https://www.ncbi.nlm.nih.gov/pubmed/36368332 http://dx.doi.org/10.1016/j.stemcr.2022.10.011

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