Notch activation during early mesoderm induction modulates emergence of the T/NK cell lineage from human iPSCs

A robust method of producing mature T cells from iPSCs is needed to realize their therapeutic potential. NOTCH1 is known to be required for the production of hematopoietic progenitor cells with T cell potential in vivo. Here we identify a critical window during mesodermal differentiation when Notch...

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Detalles Bibliográficos
Autores principales: Heinze, Dar, Park, Seonmi, McCracken, Andrew, Haratianfar, Mona, Lindstrom, Jonathan, Villacorta-Martin, Carlos, Mithal, Aditya, Wang, Feiya, Yang, Meng Wei, Murphy, George, Mostoslavsky, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768581/
https://www.ncbi.nlm.nih.gov/pubmed/36332629
http://dx.doi.org/10.1016/j.stemcr.2022.10.007

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