Anti-HMGCR Myopathy without Exposure to Statins: A Case Report

Anti-HMGCR, which was first identified in 2010, has emerged as an important mechanism of myopathogenesis in patients with exposure to statins. The availability of new detection methods has expanded the phenotypic spectrum with a subtype of population that hasn’t been exposed to the drug and whose cl...

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Autores principales: Ferriz Vivancos, Jorge, Sánchez, Marta Fandos, Timoneda, Pilar Teresa Timoneda, Benito, Goitzane Marcaida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Communications and Publications Division (CPD) of the IFCC 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768615/
https://www.ncbi.nlm.nih.gov/pubmed/36605298
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author Ferriz Vivancos, Jorge
Sánchez, Marta Fandos
Timoneda, Pilar Teresa Timoneda
Benito, Goitzane Marcaida
author_facet Ferriz Vivancos, Jorge
Sánchez, Marta Fandos
Timoneda, Pilar Teresa Timoneda
Benito, Goitzane Marcaida
author_sort Ferriz Vivancos, Jorge
collection PubMed
description Anti-HMGCR, which was first identified in 2010, has emerged as an important mechanism of myopathogenesis in patients with exposure to statins. The availability of new detection methods has expanded the phenotypic spectrum with a subtype of population that hasn’t been exposed to the drug and whose clinical, analytical, and pathological manifestations are similar. The observation by immunofluorescence of a highly specific pattern known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern) can be useful in the detection of these antibodies.
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spelling pubmed-97686152023-01-04 Anti-HMGCR Myopathy without Exposure to Statins: A Case Report Ferriz Vivancos, Jorge Sánchez, Marta Fandos Timoneda, Pilar Teresa Timoneda Benito, Goitzane Marcaida EJIFCC Case Report Anti-HMGCR, which was first identified in 2010, has emerged as an important mechanism of myopathogenesis in patients with exposure to statins. The availability of new detection methods has expanded the phenotypic spectrum with a subtype of population that hasn’t been exposed to the drug and whose clinical, analytical, and pathological manifestations are similar. The observation by immunofluorescence of a highly specific pattern known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern) can be useful in the detection of these antibodies. The Communications and Publications Division (CPD) of the IFCC 2022-12-12 /pmc/articles/PMC9768615/ /pubmed/36605298 Text en Copyright © 2022 International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This is a Platinum Open Access Journal distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ferriz Vivancos, Jorge
Sánchez, Marta Fandos
Timoneda, Pilar Teresa Timoneda
Benito, Goitzane Marcaida
Anti-HMGCR Myopathy without Exposure to Statins: A Case Report
title Anti-HMGCR Myopathy without Exposure to Statins: A Case Report
title_full Anti-HMGCR Myopathy without Exposure to Statins: A Case Report
title_fullStr Anti-HMGCR Myopathy without Exposure to Statins: A Case Report
title_full_unstemmed Anti-HMGCR Myopathy without Exposure to Statins: A Case Report
title_short Anti-HMGCR Myopathy without Exposure to Statins: A Case Report
title_sort anti-hmgcr myopathy without exposure to statins: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768615/
https://www.ncbi.nlm.nih.gov/pubmed/36605298
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