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Calcium regulates acid-sensing ion channel 3 activation by competing with protons in the channel pore and at an allosteric binding site
The extracellular Ca(2+) concentration changes locally under certain physiological and pathological conditions. Such variations affect the function of ion channels of the nervous system and consequently also neuronal signalling. We investigated here the mechanisms by which Ca(2+) controls the activi...
Autores principales: | Roy, Sophie, Johner, Niklaus, Trendafilov, Viktor, Gautschi, Ivan, Bignucolo, Olivier, Molton, Ophélie, Bernèche, Simon, Kellenberger, Stephan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768671/ https://www.ncbi.nlm.nih.gov/pubmed/36541099 http://dx.doi.org/10.1098/rsob.220243 |
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