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Polyglutamine-expanded ATXN7 alters a specific epigenetic signature underlying photoreceptor identity gene expression in SCA7 mouse retinopathy

BACKGROUND: Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder that primarily affects the cerebellum and retina. SCA7 is caused by a polyglutamine expansion in the ATXN7 protein, a subunit of the transcriptional coactivator SAGA that acetylates histone H3 to deposit narrow H3K9ac m...

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Detalles Bibliográficos
Autores principales:	Niewiadomska-Cimicka, Anna, Hache, Antoine, Le Gras, Stéphanie, Keime, Céline, Ye, Tao, Eisenmann, Aurelie, Harichane, Imen, Roux, Michel J., Messaddeq, Nadia, Clérin, Emmanuelle, Léveillard, Thierry, Trottier, Yvon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768914/ https://www.ncbi.nlm.nih.gov/pubmed/36539812 http://dx.doi.org/10.1186/s12929-022-00892-1

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