Sample size requirement in trials that use the composite endpoint major adverse cardiovascular events (MACE): new insights

BACKGROUND: The real impact of the degree of association (DoA) between endpoint components of a composite endpoint (CE) on sample size requirement (SSR) has not been explored. We estimate the impact of the DoA between death and acute myocardial infarction (AMI) on SSR of trials using use the CE of m...

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Detalles Bibliográficos
Autores principales: Marsal, Josep Ramon, Urreta-Barallobre, Iratxe, Ubeda-Carrillo, Marimar, Osorio, Dimelza, Lumbreras, Blanca, Lora, David, Fernández-Felix, Borja M., Oristrell, Gerard, Ródenas-Alesina, Eduard, Herrador, Lorena, Ballesteros, Mónica, Zamora, Javier, Pijoan, Jose I., Ribera, Aida, Ferreira-González, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769015/
https://www.ncbi.nlm.nih.gov/pubmed/36539800
http://dx.doi.org/10.1186/s13063-022-06977-4

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