Cargando…

Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature

Juvenile Xanthogranuloma (XG) is a rare disorder that belongs to the heterogeneous group of histiocytic neoplasms, characterized by a clonal expansion of non-Langerhans cell histiocytes that share a dermal macrophage phenotype. Although the head and neck region is the most common reported site of in...

Descripción completa

Detalles Bibliográficos
Autores principales: Velletrani, Gianluca, Francavilla, Beatrice, Rosati, Valentina, Padial, Belen, Anemona, Lucia, Girolamo, Stefano Di
Formato: Online Artículo Texto
Lenguaje:English
Publicado: UMF “Gr. T. Popa” Iasi Publishing House 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769079/
https://www.ncbi.nlm.nih.gov/pubmed/36628161
http://dx.doi.org/10.22551/2022.37.0904.10221
_version_ 1784854309991612416
author Velletrani, Gianluca
Francavilla, Beatrice
Rosati, Valentina
Padial, Belen
Anemona, Lucia
Girolamo, Stefano Di
author_facet Velletrani, Gianluca
Francavilla, Beatrice
Rosati, Valentina
Padial, Belen
Anemona, Lucia
Girolamo, Stefano Di
author_sort Velletrani, Gianluca
collection PubMed
description Juvenile Xanthogranuloma (XG) is a rare disorder that belongs to the heterogeneous group of histiocytic neoplasms, characterized by a clonal expansion of non-Langerhans cell histiocytes that share a dermal macrophage phenotype. Although the head and neck region is the most common reported site of involvement by the Juvenile Xanthogranuloma family, laryngeal localization is extremely rare. We report a unique case of Adult Onset Xanthogranuloma with subglottic localization, presenting as a solitary laryngeal mass without other systemic or cutaneous lesions. A review of the previously described cases of laryngeal Xanthogranuloma has been performed, highlighting 7 cases of Juvenile Xanthogranuloma and only 3 cases of Adult Onset Xanthogranuloma. Despite the extreme rarity of laryngeal localization of XG, this histiocytic neoplasm should be considered as a differential diagnosis for laryngeal masses causing airway obstruction, even in the absence of other concomitant manifestations.
format Online
Article
Text
id pubmed-9769079
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher UMF “Gr. T. Popa” Iasi Publishing House
record_format MEDLINE/PubMed
spelling pubmed-97690792023-01-09 Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature Velletrani, Gianluca Francavilla, Beatrice Rosati, Valentina Padial, Belen Anemona, Lucia Girolamo, Stefano Di Arch Clin Cases Case Report Juvenile Xanthogranuloma (XG) is a rare disorder that belongs to the heterogeneous group of histiocytic neoplasms, characterized by a clonal expansion of non-Langerhans cell histiocytes that share a dermal macrophage phenotype. Although the head and neck region is the most common reported site of involvement by the Juvenile Xanthogranuloma family, laryngeal localization is extremely rare. We report a unique case of Adult Onset Xanthogranuloma with subglottic localization, presenting as a solitary laryngeal mass without other systemic or cutaneous lesions. A review of the previously described cases of laryngeal Xanthogranuloma has been performed, highlighting 7 cases of Juvenile Xanthogranuloma and only 3 cases of Adult Onset Xanthogranuloma. Despite the extreme rarity of laryngeal localization of XG, this histiocytic neoplasm should be considered as a differential diagnosis for laryngeal masses causing airway obstruction, even in the absence of other concomitant manifestations. UMF “Gr. T. Popa” Iasi Publishing House 2022-12-19 /pmc/articles/PMC9769079/ /pubmed/36628161 http://dx.doi.org/10.22551/2022.37.0904.10221 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Velletrani, Gianluca
Francavilla, Beatrice
Rosati, Valentina
Padial, Belen
Anemona, Lucia
Girolamo, Stefano Di
Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature
title Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature
title_full Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature
title_fullStr Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature
title_full_unstemmed Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature
title_short Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature
title_sort adult onset xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769079/
https://www.ncbi.nlm.nih.gov/pubmed/36628161
http://dx.doi.org/10.22551/2022.37.0904.10221
work_keys_str_mv AT velletranigianluca adultonsetxanthogranulomapresentingasasolitarylaryngeallocalizationcasereportandreviewofliterature
AT francavillabeatrice adultonsetxanthogranulomapresentingasasolitarylaryngeallocalizationcasereportandreviewofliterature
AT rosativalentina adultonsetxanthogranulomapresentingasasolitarylaryngeallocalizationcasereportandreviewofliterature
AT padialbelen adultonsetxanthogranulomapresentingasasolitarylaryngeallocalizationcasereportandreviewofliterature
AT anemonalucia adultonsetxanthogranulomapresentingasasolitarylaryngeallocalizationcasereportandreviewofliterature
AT girolamostefanodi adultonsetxanthogranulomapresentingasasolitarylaryngeallocalizationcasereportandreviewofliterature