Cargando…
Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature
Juvenile Xanthogranuloma (XG) is a rare disorder that belongs to the heterogeneous group of histiocytic neoplasms, characterized by a clonal expansion of non-Langerhans cell histiocytes that share a dermal macrophage phenotype. Although the head and neck region is the most common reported site of in...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
UMF “Gr. T. Popa” Iasi Publishing House
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769079/ https://www.ncbi.nlm.nih.gov/pubmed/36628161 http://dx.doi.org/10.22551/2022.37.0904.10221 |
_version_ | 1784854309991612416 |
---|---|
author | Velletrani, Gianluca Francavilla, Beatrice Rosati, Valentina Padial, Belen Anemona, Lucia Girolamo, Stefano Di |
author_facet | Velletrani, Gianluca Francavilla, Beatrice Rosati, Valentina Padial, Belen Anemona, Lucia Girolamo, Stefano Di |
author_sort | Velletrani, Gianluca |
collection | PubMed |
description | Juvenile Xanthogranuloma (XG) is a rare disorder that belongs to the heterogeneous group of histiocytic neoplasms, characterized by a clonal expansion of non-Langerhans cell histiocytes that share a dermal macrophage phenotype. Although the head and neck region is the most common reported site of involvement by the Juvenile Xanthogranuloma family, laryngeal localization is extremely rare. We report a unique case of Adult Onset Xanthogranuloma with subglottic localization, presenting as a solitary laryngeal mass without other systemic or cutaneous lesions. A review of the previously described cases of laryngeal Xanthogranuloma has been performed, highlighting 7 cases of Juvenile Xanthogranuloma and only 3 cases of Adult Onset Xanthogranuloma. Despite the extreme rarity of laryngeal localization of XG, this histiocytic neoplasm should be considered as a differential diagnosis for laryngeal masses causing airway obstruction, even in the absence of other concomitant manifestations. |
format | Online Article Text |
id | pubmed-9769079 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | UMF “Gr. T. Popa” Iasi Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-97690792023-01-09 Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature Velletrani, Gianluca Francavilla, Beatrice Rosati, Valentina Padial, Belen Anemona, Lucia Girolamo, Stefano Di Arch Clin Cases Case Report Juvenile Xanthogranuloma (XG) is a rare disorder that belongs to the heterogeneous group of histiocytic neoplasms, characterized by a clonal expansion of non-Langerhans cell histiocytes that share a dermal macrophage phenotype. Although the head and neck region is the most common reported site of involvement by the Juvenile Xanthogranuloma family, laryngeal localization is extremely rare. We report a unique case of Adult Onset Xanthogranuloma with subglottic localization, presenting as a solitary laryngeal mass without other systemic or cutaneous lesions. A review of the previously described cases of laryngeal Xanthogranuloma has been performed, highlighting 7 cases of Juvenile Xanthogranuloma and only 3 cases of Adult Onset Xanthogranuloma. Despite the extreme rarity of laryngeal localization of XG, this histiocytic neoplasm should be considered as a differential diagnosis for laryngeal masses causing airway obstruction, even in the absence of other concomitant manifestations. UMF “Gr. T. Popa” Iasi Publishing House 2022-12-19 /pmc/articles/PMC9769079/ /pubmed/36628161 http://dx.doi.org/10.22551/2022.37.0904.10221 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Velletrani, Gianluca Francavilla, Beatrice Rosati, Valentina Padial, Belen Anemona, Lucia Girolamo, Stefano Di Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature |
title | Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature |
title_full | Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature |
title_fullStr | Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature |
title_full_unstemmed | Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature |
title_short | Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature |
title_sort | adult onset xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769079/ https://www.ncbi.nlm.nih.gov/pubmed/36628161 http://dx.doi.org/10.22551/2022.37.0904.10221 |
work_keys_str_mv | AT velletranigianluca adultonsetxanthogranulomapresentingasasolitarylaryngeallocalizationcasereportandreviewofliterature AT francavillabeatrice adultonsetxanthogranulomapresentingasasolitarylaryngeallocalizationcasereportandreviewofliterature AT rosativalentina adultonsetxanthogranulomapresentingasasolitarylaryngeallocalizationcasereportandreviewofliterature AT padialbelen adultonsetxanthogranulomapresentingasasolitarylaryngeallocalizationcasereportandreviewofliterature AT anemonalucia adultonsetxanthogranulomapresentingasasolitarylaryngeallocalizationcasereportandreviewofliterature AT girolamostefanodi adultonsetxanthogranulomapresentingasasolitarylaryngeallocalizationcasereportandreviewofliterature |