Evaluation of an I177L gene-based five-gene-deleted African swine fever virus as a live attenuated vaccine in pigs

African swine fever (ASF) is a highly contagious disease of domestic and wild pigs caused by the African swine fever virus (ASFV). The current research on ASF vaccines focuses on the development of naturally attenuated, isolated, or genetically engineered live viruses that have been demonstrated to...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yingnan, Xie, Zhenhua, Li, Yao, Song, Yingying, Di, Dongdong, Liu, Jingyi, Gong, Lang, Chen, Zongyan, Wu, Jinxian, Ye, Zhengqin, Liu, Jianqi, Yu, Wanqi, Lv, Lu, Zhong, Qiuping, Tian, Chuanwen, Song, Qingqing, Wang, Heng, Chen, Hongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769145/
https://www.ncbi.nlm.nih.gov/pubmed/36378022
http://dx.doi.org/10.1080/22221751.2022.2148560
_version_ 1784854324901314560
author Liu, Yingnan
Xie, Zhenhua
Li, Yao
Song, Yingying
Di, Dongdong
Liu, Jingyi
Gong, Lang
Chen, Zongyan
Wu, Jinxian
Ye, Zhengqin
Liu, Jianqi
Yu, Wanqi
Lv, Lu
Zhong, Qiuping
Tian, Chuanwen
Song, Qingqing
Wang, Heng
Chen, Hongjun
author_facet Liu, Yingnan
Xie, Zhenhua
Li, Yao
Song, Yingying
Di, Dongdong
Liu, Jingyi
Gong, Lang
Chen, Zongyan
Wu, Jinxian
Ye, Zhengqin
Liu, Jianqi
Yu, Wanqi
Lv, Lu
Zhong, Qiuping
Tian, Chuanwen
Song, Qingqing
Wang, Heng
Chen, Hongjun
author_sort Liu, Yingnan
collection PubMed
description African swine fever (ASF) is a highly contagious disease of domestic and wild pigs caused by the African swine fever virus (ASFV). The current research on ASF vaccines focuses on the development of naturally attenuated, isolated, or genetically engineered live viruses that have been demonstrated to produce reliable immunity. As a result, a genetically engineered virus containing five genes deletion was synthesized based on ASFV Chinese strain GZ201801, named ASFV-GZΔI177LΔCD2vΔMGF. The five-gene-deleted ASFV was safe and fully attenuated in pigs and provides reliable protection against the parental ASFV strain challenge. This indicates that the five-gene-deleted ASFV is a potential candidate for a live attenuated vaccine that could control the spread of ASFV.
format Online
Article
Text
id pubmed-9769145
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-97691452022-12-22 Evaluation of an I177L gene-based five-gene-deleted African swine fever virus as a live attenuated vaccine in pigs Liu, Yingnan Xie, Zhenhua Li, Yao Song, Yingying Di, Dongdong Liu, Jingyi Gong, Lang Chen, Zongyan Wu, Jinxian Ye, Zhengqin Liu, Jianqi Yu, Wanqi Lv, Lu Zhong, Qiuping Tian, Chuanwen Song, Qingqing Wang, Heng Chen, Hongjun Emerg Microbes Infect Research Article African swine fever (ASF) is a highly contagious disease of domestic and wild pigs caused by the African swine fever virus (ASFV). The current research on ASF vaccines focuses on the development of naturally attenuated, isolated, or genetically engineered live viruses that have been demonstrated to produce reliable immunity. As a result, a genetically engineered virus containing five genes deletion was synthesized based on ASFV Chinese strain GZ201801, named ASFV-GZΔI177LΔCD2vΔMGF. The five-gene-deleted ASFV was safe and fully attenuated in pigs and provides reliable protection against the parental ASFV strain challenge. This indicates that the five-gene-deleted ASFV is a potential candidate for a live attenuated vaccine that could control the spread of ASFV. Taylor & Francis 2022-12-18 /pmc/articles/PMC9769145/ /pubmed/36378022 http://dx.doi.org/10.1080/22221751.2022.2148560 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Yingnan
Xie, Zhenhua
Li, Yao
Song, Yingying
Di, Dongdong
Liu, Jingyi
Gong, Lang
Chen, Zongyan
Wu, Jinxian
Ye, Zhengqin
Liu, Jianqi
Yu, Wanqi
Lv, Lu
Zhong, Qiuping
Tian, Chuanwen
Song, Qingqing
Wang, Heng
Chen, Hongjun
Evaluation of an I177L gene-based five-gene-deleted African swine fever virus as a live attenuated vaccine in pigs
title Evaluation of an I177L gene-based five-gene-deleted African swine fever virus as a live attenuated vaccine in pigs
title_full Evaluation of an I177L gene-based five-gene-deleted African swine fever virus as a live attenuated vaccine in pigs
title_fullStr Evaluation of an I177L gene-based five-gene-deleted African swine fever virus as a live attenuated vaccine in pigs
title_full_unstemmed Evaluation of an I177L gene-based five-gene-deleted African swine fever virus as a live attenuated vaccine in pigs
title_short Evaluation of an I177L gene-based five-gene-deleted African swine fever virus as a live attenuated vaccine in pigs
title_sort evaluation of an i177l gene-based five-gene-deleted african swine fever virus as a live attenuated vaccine in pigs
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769145/
https://www.ncbi.nlm.nih.gov/pubmed/36378022
http://dx.doi.org/10.1080/22221751.2022.2148560
work_keys_str_mv AT liuyingnan evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT xiezhenhua evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT liyao evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT songyingying evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT didongdong evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT liujingyi evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT gonglang evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT chenzongyan evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT wujinxian evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT yezhengqin evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT liujianqi evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT yuwanqi evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT lvlu evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT zhongqiuping evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT tianchuanwen evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT songqingqing evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT wangheng evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs
AT chenhongjun evaluationofani177lgenebasedfivegenedeletedafricanswinefevervirusasaliveattenuatedvaccineinpigs

Ejemplares similares