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Cross-Species Permissivity: Structure of a Goat Adeno-Associated Virus and Its Complex with the Human Receptor AAVR

Adeno-associated virus (AAV) is a small ssDNA satellite virus of high interest (in recombinant form) as a safe and effective gene therapy vector. AAV’s human cell entry receptor (AAVR) contains polycystic kidney disease (PKD) domains bound by AAV. Seeking understanding of the spectrum of interaction...

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Detalles Bibliográficos
Autores principales:	Large, Edward E., Silveria, Mark A., Weerakoon, Onellah, White, Tommi A., Chapman, Michael S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Structure and Assembly
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769368/ https://www.ncbi.nlm.nih.gov/pubmed/36453885 http://dx.doi.org/10.1128/jvi.01484-22

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