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The BCL-2 Inhibitor Venetoclax Augments Immune Effector Function Mediated by Fas Ligand, TRAIL, and Perforin/Granzyme B, Resulting in Reduced Plasma Viremia and Decreased HIV Reservoir Size during Acute HIV Infection in a Humanized Mouse Model

The BCL-2 prosurvival protein is implicated in HIV persistence and is a potential therapeutic target for HIV eradication efforts. We now know that cells harboring HIV are preferentially enriched for high BCL-2 expression, enabling their survival, and that the BCL-2 inhibitor venetoclax promotes the...

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Detalles Bibliográficos
Autores principales:	Chandrasekar, Aswath P., Cummins, Nathan W., Natesampillai, Sekar, Misra, Anisha, Alto, Alecia, Laird, Greg, Badley, Andrew D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Vaccines and Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769373/ https://www.ncbi.nlm.nih.gov/pubmed/36448802 http://dx.doi.org/10.1128/jvi.01730-22

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