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Rational Design of Live-Attenuated Vaccines against Genome-Reduced Pathogens

To develop safe and highly effective live vaccines, rational vaccine design is necessary. Here, we sought a simple approach to rationally develop a safe attenuated vaccine against the genome-reduced pathogen Erysipelothrix rhusiopathiae. We examined the mRNA expression of all conserved amino acid bi...

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Detalles Bibliográficos
Autores principales:	Nishikawa, Sayaka, Ogawa, Yohsuke, Shiraiwa, Kazumasa, Nozawa, Rieko, Nakayama, Momoko, Eguchi, Masahiro, Shimoji, Yoshihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769512/ https://www.ncbi.nlm.nih.gov/pubmed/36453908 http://dx.doi.org/10.1128/spectrum.03776-22

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