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Generation of Angiotensin-Converting Enzyme 2/Transmembrane Protease Serine 2-Double-Positive Human Induced Pluripotent Stem Cell-Derived Spheroids for Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Drug Evaluation

We newly generated two human induced pluripotent stem cell (hiPSC)-derived spheroid lines, termed Spheroids_(4M)(ACE2-TMPRSS2) and Spheroids_(15M63)(ACE2-TMPRSS2), both of which express angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2), which are critical for sever...

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Detalles Bibliográficos
Autores principales:	Higashi-Kuwata, Nobuyo, Yabe, Shigeharu G., Fukuda, Satsuki, Nishida, Junko, Tamura-Nakano, Miwa, Hattori, Shin-ichiro, Okochi, Hitoshi, Mitsuya, Hiroaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Observation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769601/ https://www.ncbi.nlm.nih.gov/pubmed/36314907 http://dx.doi.org/10.1128/spectrum.03490-22

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