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Spatial and temporal frequency band changes during infarct induction, infarct progression, and spreading depolarizations in the gyrencephalic brain

AIM: To describe the spatial and temporal electrocorticographic (ECoG) changes after middle cerebral artery occlusion (MCAo), including those caused by spreading depolarization (SD) in the pig brain. METHODS: The left middle cerebral arteries (MCAs) were clipped in six pigs. The clipping procedure l...

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Autores principales: Kentar, Modar, Díaz-Peregrino, Roberto, Trenado, Carlos, Sánchez-Porras, Renán, San-Juan, Daniel, Ramírez-Cuapio, F. Leonardo, Holzwarth, Niklas, Maier-Hein, Lena, Woitzik, Johannes, Santos, Edgar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769704/
https://www.ncbi.nlm.nih.gov/pubmed/36570832
http://dx.doi.org/10.3389/fnins.2022.1025967
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author Kentar, Modar
Díaz-Peregrino, Roberto
Trenado, Carlos
Sánchez-Porras, Renán
San-Juan, Daniel
Ramírez-Cuapio, F. Leonardo
Holzwarth, Niklas
Maier-Hein, Lena
Woitzik, Johannes
Santos, Edgar
author_facet Kentar, Modar
Díaz-Peregrino, Roberto
Trenado, Carlos
Sánchez-Porras, Renán
San-Juan, Daniel
Ramírez-Cuapio, F. Leonardo
Holzwarth, Niklas
Maier-Hein, Lena
Woitzik, Johannes
Santos, Edgar
author_sort Kentar, Modar
collection PubMed
description AIM: To describe the spatial and temporal electrocorticographic (ECoG) changes after middle cerebral artery occlusion (MCAo), including those caused by spreading depolarization (SD) in the pig brain. METHODS: The left middle cerebral arteries (MCAs) were clipped in six pigs. The clipping procedure lasted between 8 and 12 min, achieving a permanent occlusion (MCAo). Five-contact ECoG stripes were placed bilaterally over the frontoparietal cortices corresponding to the irrigation territory of the MCA and anterior cerebral artery (ACA). ECoG recordings were performed around 24 h: 1 h before and 23 h after the MCAo, and SDs were quantified. Five-minute ECoG signal segments were sampled before, 5 min, and 4, 8, and 12 h after cerebral artery occlusion and before, during, and after the negative direct current shift of the SDs. The power spectrum of the signals was decomposed into delta, theta, alpha, beta, and gamma bands. Descriptive statistics, Wilcoxon matched-pairs signed-rank tests, and Friedman tests were performed. RESULTS: Electrodes close to the MCAo showed instant decay in all frequency bands and SD onset during the first 5 h. Electrodes far from the MCAo exhibited immediate loss of fast frequencies and progressive decline of slow frequencies with an increased SD incidence between 6 and 14 h. After 8 h, the ACA electrode reported a secondary reduction of all frequency bands except gamma and high SD incidence within 12–17 h. During the SD, all electrodes showed a decline in all frequency bands. After SD passage, frequency band recovery was impaired only in MCA electrodes. CONCLUSION: ECoG can identify infarct progression and secondary brain injury. Severe disturbances in all the frequency bands are generated in the cortices where the SDs are passing by.
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spelling pubmed-97697042022-12-22 Spatial and temporal frequency band changes during infarct induction, infarct progression, and spreading depolarizations in the gyrencephalic brain Kentar, Modar Díaz-Peregrino, Roberto Trenado, Carlos Sánchez-Porras, Renán San-Juan, Daniel Ramírez-Cuapio, F. Leonardo Holzwarth, Niklas Maier-Hein, Lena Woitzik, Johannes Santos, Edgar Front Neurosci Neuroscience AIM: To describe the spatial and temporal electrocorticographic (ECoG) changes after middle cerebral artery occlusion (MCAo), including those caused by spreading depolarization (SD) in the pig brain. METHODS: The left middle cerebral arteries (MCAs) were clipped in six pigs. The clipping procedure lasted between 8 and 12 min, achieving a permanent occlusion (MCAo). Five-contact ECoG stripes were placed bilaterally over the frontoparietal cortices corresponding to the irrigation territory of the MCA and anterior cerebral artery (ACA). ECoG recordings were performed around 24 h: 1 h before and 23 h after the MCAo, and SDs were quantified. Five-minute ECoG signal segments were sampled before, 5 min, and 4, 8, and 12 h after cerebral artery occlusion and before, during, and after the negative direct current shift of the SDs. The power spectrum of the signals was decomposed into delta, theta, alpha, beta, and gamma bands. Descriptive statistics, Wilcoxon matched-pairs signed-rank tests, and Friedman tests were performed. RESULTS: Electrodes close to the MCAo showed instant decay in all frequency bands and SD onset during the first 5 h. Electrodes far from the MCAo exhibited immediate loss of fast frequencies and progressive decline of slow frequencies with an increased SD incidence between 6 and 14 h. After 8 h, the ACA electrode reported a secondary reduction of all frequency bands except gamma and high SD incidence within 12–17 h. During the SD, all electrodes showed a decline in all frequency bands. After SD passage, frequency band recovery was impaired only in MCA electrodes. CONCLUSION: ECoG can identify infarct progression and secondary brain injury. Severe disturbances in all the frequency bands are generated in the cortices where the SDs are passing by. Frontiers Media S.A. 2022-12-05 /pmc/articles/PMC9769704/ /pubmed/36570832 http://dx.doi.org/10.3389/fnins.2022.1025967 Text en Copyright © 2022 Kentar, Díaz-Peregrino, Trenado, Sánchez-Porras, San-Juan, Ramírez-Cuapio, Holzwarth, Maier-Hein, Woitzik and Santos. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Kentar, Modar
Díaz-Peregrino, Roberto
Trenado, Carlos
Sánchez-Porras, Renán
San-Juan, Daniel
Ramírez-Cuapio, F. Leonardo
Holzwarth, Niklas
Maier-Hein, Lena
Woitzik, Johannes
Santos, Edgar
Spatial and temporal frequency band changes during infarct induction, infarct progression, and spreading depolarizations in the gyrencephalic brain
title Spatial and temporal frequency band changes during infarct induction, infarct progression, and spreading depolarizations in the gyrencephalic brain
title_full Spatial and temporal frequency band changes during infarct induction, infarct progression, and spreading depolarizations in the gyrencephalic brain
title_fullStr Spatial and temporal frequency band changes during infarct induction, infarct progression, and spreading depolarizations in the gyrencephalic brain
title_full_unstemmed Spatial and temporal frequency band changes during infarct induction, infarct progression, and spreading depolarizations in the gyrencephalic brain
title_short Spatial and temporal frequency band changes during infarct induction, infarct progression, and spreading depolarizations in the gyrencephalic brain
title_sort spatial and temporal frequency band changes during infarct induction, infarct progression, and spreading depolarizations in the gyrencephalic brain
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769704/
https://www.ncbi.nlm.nih.gov/pubmed/36570832
http://dx.doi.org/10.3389/fnins.2022.1025967
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