CRISPR-Cas9 Editing Induces Loss of Heterozygosity in the Pathogenic Yeast Candida parapsilosis

Genetic manipulation is often used to study gene function. However, unplanned genome changes (including single nucleotide polymorphisms [SNPs], aneuploidy, and loss of heterozygosity [LOH]) can affect the phenotypic traits of the engineered strains. Here, we compared the effect of classical deletion...

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Detalles Bibliográficos
Autores principales: Lombardi, Lisa, Bergin, Sean A., Ryan, Adam, Zuniga-Soto, Evelyn, Butler, Geraldine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769790/
https://www.ncbi.nlm.nih.gov/pubmed/36416551
http://dx.doi.org/10.1128/msphere.00393-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769790/
https://www.ncbi.nlm.nih.gov/pubmed/36416551
http://dx.doi.org/10.1128/msphere.00393-22

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