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25-Hydroxycholesterol Mediates Cholesterol Metabolism to Restrict Porcine Deltacoronavirus Infection via Suppression of Transforming Growth Factor β1

Porcine deltacoronavirus (PDCoV), an emerging enteropathogenic coronavirus in pigs, is one of the major pathogens for lethal watery diarrhea in piglets and poses a threat to public health because of its potential for interspecies transmission to humans. 25-Hydroxycholesterol (25HC), a derivative of...

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Detalles Bibliográficos
Autores principales: Zhang, Jialu, Yang, Guanghui, Wang, Xuefei, Zhu, Yaohong, Wang, Jiufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769798/
https://www.ncbi.nlm.nih.gov/pubmed/36314946
http://dx.doi.org/10.1128/spectrum.02198-22