In Vitro Profiling of the Synthetic RNA Polymerase Inhibitor MMV688845 against Mycobacterium abscessus

In a library screen of tuberculosis-active compounds for anti-Mycobacterium abscessus activity, we previously identified the synthetic phenylalanine amide MMV688845. In Mycobacterium tuberculosis, this class was shown to target the RpoB subunit of RNA polymerase, engaging a binding site distinct fro...

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Detalles Bibliográficos
Autores principales: Mann, Lea, Ganapathy, Uday S., Abdelaziz, Rana, Lang, Markus, Zimmerman, Matthew D., Dartois, Véronique, Dick, Thomas, Richter, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769904/
https://www.ncbi.nlm.nih.gov/pubmed/36377951
http://dx.doi.org/10.1128/spectrum.02760-22

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