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CONCURRENT CHANGES IN COGNITIVE FUNCTION AND FUNCTIONAL LIMITATIONS: A BIVARIATE LATENT TRAJECTORY ANALYSIS

With a rapidly aging global population, declines in cognition and functional abilities are an increasingly salient challenge and fear among many older adults. Researchers and clinicians often study changes in cognition and changes in functional limitations as separate trajectories although they freq...

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Autores principales: Handing, Elizabeth, Aichele, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9770131/
http://dx.doi.org/10.1093/geroni/igac059.788
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author Handing, Elizabeth
Aichele, Stephen
author_facet Handing, Elizabeth
Aichele, Stephen
author_sort Handing, Elizabeth
collection PubMed
description With a rapidly aging global population, declines in cognition and functional abilities are an increasingly salient challenge and fear among many older adults. Researchers and clinicians often study changes in cognition and changes in functional limitations as separate trajectories although they frequently co-occur. In this study, we used two-stage structural equation modeling (SEM) to estimate longitudinal trajectories of cognitive and functional limitations using data from the Health and Retirement Study (2010-2016) (N = 12,431, aged 50–91). First, individuals’ longitudinal factor scores (at three measurement occasions, spanning 6 years) were estimated for cognition (indicated by verbal fluency, numeracy, and recall memory) and functional limitations (indicated by difficulties performing daily living activities, instrumental activities, and mobility). A bivariate latent trajectory model was then fit to these scores. Model fit was acceptable (CFI = .91; RMSEA = .036). Parameter estimates showed that, on average, cognition declined slightly (-.08SD/decade) and functional limitations increased gradually (0.38SD/decade). Importantly, individual cognitive declines were significantly correlated with increases in functional limitation (r = -.19, p < .001). This study fills an important research gap by using advanced statistical modeling (bivariate latent growth models) to examine the joint trajectory of cognition and functional decline which underscores the need to consider the interplay of these two abilities. Methods that quantify both individual and group trajectories can aid in better identification of aging patterns and lead to new ways of thinking about interventions to reduce the burden of concurrent decline.
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spelling pubmed-97701312022-12-22 CONCURRENT CHANGES IN COGNITIVE FUNCTION AND FUNCTIONAL LIMITATIONS: A BIVARIATE LATENT TRAJECTORY ANALYSIS Handing, Elizabeth Aichele, Stephen Innov Aging Abstracts With a rapidly aging global population, declines in cognition and functional abilities are an increasingly salient challenge and fear among many older adults. Researchers and clinicians often study changes in cognition and changes in functional limitations as separate trajectories although they frequently co-occur. In this study, we used two-stage structural equation modeling (SEM) to estimate longitudinal trajectories of cognitive and functional limitations using data from the Health and Retirement Study (2010-2016) (N = 12,431, aged 50–91). First, individuals’ longitudinal factor scores (at three measurement occasions, spanning 6 years) were estimated for cognition (indicated by verbal fluency, numeracy, and recall memory) and functional limitations (indicated by difficulties performing daily living activities, instrumental activities, and mobility). A bivariate latent trajectory model was then fit to these scores. Model fit was acceptable (CFI = .91; RMSEA = .036). Parameter estimates showed that, on average, cognition declined slightly (-.08SD/decade) and functional limitations increased gradually (0.38SD/decade). Importantly, individual cognitive declines were significantly correlated with increases in functional limitation (r = -.19, p < .001). This study fills an important research gap by using advanced statistical modeling (bivariate latent growth models) to examine the joint trajectory of cognition and functional decline which underscores the need to consider the interplay of these two abilities. Methods that quantify both individual and group trajectories can aid in better identification of aging patterns and lead to new ways of thinking about interventions to reduce the burden of concurrent decline. Oxford University Press 2022-12-20 /pmc/articles/PMC9770131/ http://dx.doi.org/10.1093/geroni/igac059.788 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Handing, Elizabeth
Aichele, Stephen
CONCURRENT CHANGES IN COGNITIVE FUNCTION AND FUNCTIONAL LIMITATIONS: A BIVARIATE LATENT TRAJECTORY ANALYSIS
title CONCURRENT CHANGES IN COGNITIVE FUNCTION AND FUNCTIONAL LIMITATIONS: A BIVARIATE LATENT TRAJECTORY ANALYSIS
title_full CONCURRENT CHANGES IN COGNITIVE FUNCTION AND FUNCTIONAL LIMITATIONS: A BIVARIATE LATENT TRAJECTORY ANALYSIS
title_fullStr CONCURRENT CHANGES IN COGNITIVE FUNCTION AND FUNCTIONAL LIMITATIONS: A BIVARIATE LATENT TRAJECTORY ANALYSIS
title_full_unstemmed CONCURRENT CHANGES IN COGNITIVE FUNCTION AND FUNCTIONAL LIMITATIONS: A BIVARIATE LATENT TRAJECTORY ANALYSIS
title_short CONCURRENT CHANGES IN COGNITIVE FUNCTION AND FUNCTIONAL LIMITATIONS: A BIVARIATE LATENT TRAJECTORY ANALYSIS
title_sort concurrent changes in cognitive function and functional limitations: a bivariate latent trajectory analysis
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9770131/
http://dx.doi.org/10.1093/geroni/igac059.788
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