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AFFECTIVE REACTIVITY TO DAILY STRESSORS AND IMMUNE GENE EXPRESSION IN THE MIDUS STUDY

Past research indicates that an individual’s affective reactivity to daily stressors is associated with elevated levels of inflammatory biomarkers such as interleukin-6 and C-reactive protein. Here, we assessed individuals’ positive and negative affective reactivity to daily stressors, and their ass...

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Autores principales: Apsley, Abner, Lee, Sun Ah, Bhat, Aarti, Almeida, David, Shalev, Idan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9770490/
http://dx.doi.org/10.1093/geroni/igac059.1635
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author Apsley, Abner
Lee, Sun Ah
Bhat, Aarti
Almeida, David
Shalev, Idan
author_facet Apsley, Abner
Lee, Sun Ah
Bhat, Aarti
Almeida, David
Shalev, Idan
author_sort Apsley, Abner
collection PubMed
description Past research indicates that an individual’s affective reactivity to daily stressors is associated with elevated levels of inflammatory biomarkers such as interleukin-6 and C-reactive protein. Here, we assessed individuals’ positive and negative affective reactivity to daily stressors, and their association with expression levels of genes in the conserved transcriptional response to adversity (CTRA; proinflammatory and type-1 interferon antiviral genes). We hypothesize that gene expression levels of CTRA genes are a possible explanatory mechanistic link between higher levels of affective reactivity and inflammatory markers. Our study included 199 individuals from the Midlife in the United States Refresher study (ages 26-71, 52.8% female, and 17.9% non-white) who participated in the Gene Expression and Daily Diary Projects. Individuals provided whole blood for gene expression analysis and completed an 8-day telephone interview to assess daily experiences. Positive and negative affective reactivity scores were used to indicate magnitude of an individual’s changes in daily affect on stressor-days versus non-stressor-days, and were computed using multilevel modeling. Three CTRA gene expression scores were created for each individual, representing the average expression of proinflammatory, type-1 interferon, and a combination of both. Preliminary findings suggest a negative association between the CTRA composite score and negative affective reactivity to daily stressors (β = -0.963, p = 0.034), controlling for covariates. Further analyses will use affective reactivity to predict individual CTRA genes, correcting for multiple testing. This study will be the first to examine the relationship between daily assessments of emotions and gene expression levels in a representative U.S. cohort.
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spelling pubmed-97704902022-12-22 AFFECTIVE REACTIVITY TO DAILY STRESSORS AND IMMUNE GENE EXPRESSION IN THE MIDUS STUDY Apsley, Abner Lee, Sun Ah Bhat, Aarti Almeida, David Shalev, Idan Innov Aging Abstracts Past research indicates that an individual’s affective reactivity to daily stressors is associated with elevated levels of inflammatory biomarkers such as interleukin-6 and C-reactive protein. Here, we assessed individuals’ positive and negative affective reactivity to daily stressors, and their association with expression levels of genes in the conserved transcriptional response to adversity (CTRA; proinflammatory and type-1 interferon antiviral genes). We hypothesize that gene expression levels of CTRA genes are a possible explanatory mechanistic link between higher levels of affective reactivity and inflammatory markers. Our study included 199 individuals from the Midlife in the United States Refresher study (ages 26-71, 52.8% female, and 17.9% non-white) who participated in the Gene Expression and Daily Diary Projects. Individuals provided whole blood for gene expression analysis and completed an 8-day telephone interview to assess daily experiences. Positive and negative affective reactivity scores were used to indicate magnitude of an individual’s changes in daily affect on stressor-days versus non-stressor-days, and were computed using multilevel modeling. Three CTRA gene expression scores were created for each individual, representing the average expression of proinflammatory, type-1 interferon, and a combination of both. Preliminary findings suggest a negative association between the CTRA composite score and negative affective reactivity to daily stressors (β = -0.963, p = 0.034), controlling for covariates. Further analyses will use affective reactivity to predict individual CTRA genes, correcting for multiple testing. This study will be the first to examine the relationship between daily assessments of emotions and gene expression levels in a representative U.S. cohort. Oxford University Press 2022-12-20 /pmc/articles/PMC9770490/ http://dx.doi.org/10.1093/geroni/igac059.1635 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Apsley, Abner
Lee, Sun Ah
Bhat, Aarti
Almeida, David
Shalev, Idan
AFFECTIVE REACTIVITY TO DAILY STRESSORS AND IMMUNE GENE EXPRESSION IN THE MIDUS STUDY
title AFFECTIVE REACTIVITY TO DAILY STRESSORS AND IMMUNE GENE EXPRESSION IN THE MIDUS STUDY
title_full AFFECTIVE REACTIVITY TO DAILY STRESSORS AND IMMUNE GENE EXPRESSION IN THE MIDUS STUDY
title_fullStr AFFECTIVE REACTIVITY TO DAILY STRESSORS AND IMMUNE GENE EXPRESSION IN THE MIDUS STUDY
title_full_unstemmed AFFECTIVE REACTIVITY TO DAILY STRESSORS AND IMMUNE GENE EXPRESSION IN THE MIDUS STUDY
title_short AFFECTIVE REACTIVITY TO DAILY STRESSORS AND IMMUNE GENE EXPRESSION IN THE MIDUS STUDY
title_sort affective reactivity to daily stressors and immune gene expression in the midus study
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9770490/
http://dx.doi.org/10.1093/geroni/igac059.1635
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