Cargando…

MENTAL-SOMATIC MULTIMORBIDITY IN GROUP-BASED TRAJECTORIES OF COGNITIVE FUNCTION FOR MIDDLE-AGED AND OLDER ADULTS

Somatic and mental multimorbidity contributes to cognitive decline. The study aims to identify distinct trajectories of cognitive performance among middle-aged and older adults, and to examine the contribution of specific somatic and mental multimorbidity combinations on subsequent risk of cognitive...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Siting, Nagel, Corey, Botoseneanu, Anda, Allore, Heather, Newsom, Jason, Thielke, Stephen, Kaye, Jeffrey, Quiñones, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9770737/
http://dx.doi.org/10.1093/geroni/igac059.2273
_version_ 1784854670792982528
author Chen, Siting
Nagel, Corey
Botoseneanu, Anda
Allore, Heather
Newsom, Jason
Thielke, Stephen
Kaye, Jeffrey
Quiñones, Ana
author_facet Chen, Siting
Nagel, Corey
Botoseneanu, Anda
Allore, Heather
Newsom, Jason
Thielke, Stephen
Kaye, Jeffrey
Quiñones, Ana
author_sort Chen, Siting
collection PubMed
description Somatic and mental multimorbidity contributes to cognitive decline. The study aims to identify distinct trajectories of cognitive performance among middle-aged and older adults, and to examine the contribution of specific somatic and mental multimorbidity combinations on subsequent risk of cognitive impairment. We used group-based trajectory modeling to identify trajectories of cognitive impairment risk among participants in the Health & Retirement Study during years 1998-2016 (N=20,372). We included time-invariant sociodemographic factors (sex, race/ethnicity, education) to quantify their association with trajectory class membership, and time-varying multimorbidity combinations to examine their relative impact on observed trajectories. Four somatic-mental multimorbidity combinations were analyzed: somatic multimorbidity (two or more of the following: heart disease, lung disease, hypertension, arthritis, diabetes, cancer), stroke-multimorbidity (any somatic including stroke); depressive-multimorbidity (any somatic including high depressive symptoms); and stroke and depressive multimorbidity (including both stroke and high depressive symptoms). We identified three trajectory classes of cognitive impairment: low baseline risk with gradual increase (55.1%); low baseline risk with rapid increase (32.8%); and high baseline risk with gradual increase (12.1%). In the group with low baseline risk with rapid increase, stroke-multimorbidity (OR: 2.40, 95%CI: 2.11, 2.74) and depressive-multimorbidity (OR: 1.65, 95%CI: 1.50,1.81) each had higher odds of cognitive impairment relative to somatic multimorbidity. Similarly, stroke and depressive multimorbidity (OR: 3.46, 95%CI: 2.85, 4.21) was associated with higher odds of cognitive impairment compared with somatic multimorbidity. This study highlights the importance of risk modification for somatic and mental multimorbidity combinations from mid-life to inform interventions to sustain cognitive performance.
format Online
Article
Text
id pubmed-9770737
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-97707372022-12-22 MENTAL-SOMATIC MULTIMORBIDITY IN GROUP-BASED TRAJECTORIES OF COGNITIVE FUNCTION FOR MIDDLE-AGED AND OLDER ADULTS Chen, Siting Nagel, Corey Botoseneanu, Anda Allore, Heather Newsom, Jason Thielke, Stephen Kaye, Jeffrey Quiñones, Ana Innov Aging Abstracts Somatic and mental multimorbidity contributes to cognitive decline. The study aims to identify distinct trajectories of cognitive performance among middle-aged and older adults, and to examine the contribution of specific somatic and mental multimorbidity combinations on subsequent risk of cognitive impairment. We used group-based trajectory modeling to identify trajectories of cognitive impairment risk among participants in the Health & Retirement Study during years 1998-2016 (N=20,372). We included time-invariant sociodemographic factors (sex, race/ethnicity, education) to quantify their association with trajectory class membership, and time-varying multimorbidity combinations to examine their relative impact on observed trajectories. Four somatic-mental multimorbidity combinations were analyzed: somatic multimorbidity (two or more of the following: heart disease, lung disease, hypertension, arthritis, diabetes, cancer), stroke-multimorbidity (any somatic including stroke); depressive-multimorbidity (any somatic including high depressive symptoms); and stroke and depressive multimorbidity (including both stroke and high depressive symptoms). We identified three trajectory classes of cognitive impairment: low baseline risk with gradual increase (55.1%); low baseline risk with rapid increase (32.8%); and high baseline risk with gradual increase (12.1%). In the group with low baseline risk with rapid increase, stroke-multimorbidity (OR: 2.40, 95%CI: 2.11, 2.74) and depressive-multimorbidity (OR: 1.65, 95%CI: 1.50,1.81) each had higher odds of cognitive impairment relative to somatic multimorbidity. Similarly, stroke and depressive multimorbidity (OR: 3.46, 95%CI: 2.85, 4.21) was associated with higher odds of cognitive impairment compared with somatic multimorbidity. This study highlights the importance of risk modification for somatic and mental multimorbidity combinations from mid-life to inform interventions to sustain cognitive performance. Oxford University Press 2022-12-20 /pmc/articles/PMC9770737/ http://dx.doi.org/10.1093/geroni/igac059.2273 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Chen, Siting
Nagel, Corey
Botoseneanu, Anda
Allore, Heather
Newsom, Jason
Thielke, Stephen
Kaye, Jeffrey
Quiñones, Ana
MENTAL-SOMATIC MULTIMORBIDITY IN GROUP-BASED TRAJECTORIES OF COGNITIVE FUNCTION FOR MIDDLE-AGED AND OLDER ADULTS
title MENTAL-SOMATIC MULTIMORBIDITY IN GROUP-BASED TRAJECTORIES OF COGNITIVE FUNCTION FOR MIDDLE-AGED AND OLDER ADULTS
title_full MENTAL-SOMATIC MULTIMORBIDITY IN GROUP-BASED TRAJECTORIES OF COGNITIVE FUNCTION FOR MIDDLE-AGED AND OLDER ADULTS
title_fullStr MENTAL-SOMATIC MULTIMORBIDITY IN GROUP-BASED TRAJECTORIES OF COGNITIVE FUNCTION FOR MIDDLE-AGED AND OLDER ADULTS
title_full_unstemmed MENTAL-SOMATIC MULTIMORBIDITY IN GROUP-BASED TRAJECTORIES OF COGNITIVE FUNCTION FOR MIDDLE-AGED AND OLDER ADULTS
title_short MENTAL-SOMATIC MULTIMORBIDITY IN GROUP-BASED TRAJECTORIES OF COGNITIVE FUNCTION FOR MIDDLE-AGED AND OLDER ADULTS
title_sort mental-somatic multimorbidity in group-based trajectories of cognitive function for middle-aged and older adults
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9770737/
http://dx.doi.org/10.1093/geroni/igac059.2273
work_keys_str_mv AT chensiting mentalsomaticmultimorbidityingroupbasedtrajectoriesofcognitivefunctionformiddleagedandolderadults
AT nagelcorey mentalsomaticmultimorbidityingroupbasedtrajectoriesofcognitivefunctionformiddleagedandolderadults
AT botoseneanuanda mentalsomaticmultimorbidityingroupbasedtrajectoriesofcognitivefunctionformiddleagedandolderadults
AT alloreheather mentalsomaticmultimorbidityingroupbasedtrajectoriesofcognitivefunctionformiddleagedandolderadults
AT newsomjason mentalsomaticmultimorbidityingroupbasedtrajectoriesofcognitivefunctionformiddleagedandolderadults
AT thielkestephen mentalsomaticmultimorbidityingroupbasedtrajectoriesofcognitivefunctionformiddleagedandolderadults
AT kayejeffrey mentalsomaticmultimorbidityingroupbasedtrajectoriesofcognitivefunctionformiddleagedandolderadults
AT quinonesana mentalsomaticmultimorbidityingroupbasedtrajectoriesofcognitivefunctionformiddleagedandolderadults