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Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system

The oral protease inhibitor nirmatrelvir is of key importance for prevention of severe coronavirus disease 2019 (COVID-19). To facilitate resistance monitoring, we studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from nirmatrelvir in cell culture. Resistant variants harbor...

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Detalles Bibliográficos
Autores principales:	Zhou, Yuyong, Gammeltoft, Karen Anbro, Ryberg, Line Abildgaard, Pham, Long V., Tjørnelund, Helena Damtoft, Binderup, Alekxander, Duarte Hernandez, Carlos Rene, Fernandez-Antunez, Carlota, Offersgaard, Anna, Fahnøe, Ulrik, Peters, Günther Herbert Johannes, Ramirez, Santseharay, Bukh, Jens, Gottwein, Judith Margarete
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9770952/ https://www.ncbi.nlm.nih.gov/pubmed/36542720 http://dx.doi.org/10.1126/sciadv.add7197

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