TAp63 determines the fate of oocytes against DNA damage

Cyclophosphamide and doxorubicin lead to premature ovarian insufficiency as an off-target effect. However, their oocyte death pathway has been debated. Here, we clarified the precise mechanism of ovarian depletion induced by cyclophosphamide and doxorubicin. Dormant oocytes instead of activated oocy...

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Detalles Bibliográficos
Autores principales: Luan, Yi, Yu, Seok-Yeong, Abazarikia, Amirhossein, Dong, Rosemary, Kim, So-Youn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9770984/
https://www.ncbi.nlm.nih.gov/pubmed/36542718
http://dx.doi.org/10.1126/sciadv.ade1846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9770984/
https://www.ncbi.nlm.nih.gov/pubmed/36542718
http://dx.doi.org/10.1126/sciadv.ade1846

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