Cargando…
AGE-RELATED DIFFERENCES IN THEORY OF MIND: A TIME-VARYING FUNCTIONAL CONNECTIVITY APPROACH
Theory of Mind (ToM) refers to the act of inferring someone’s inner state, such as their emotions and thoughts. Previous work also demonstrated that ToM performance declines across age, but the mechanisms underlying this are not well-understood. The brain regions underlying ToM are generally in the...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771047/ http://dx.doi.org/10.1093/geroni/igac059.2080 |
_version_ | 1784854733824983040 |
---|---|
author | Rincon, Samuel Naranjo Betzel, Richard Krendl, Anne |
author_facet | Rincon, Samuel Naranjo Betzel, Richard Krendl, Anne |
author_sort | Rincon, Samuel Naranjo |
collection | PubMed |
description | Theory of Mind (ToM) refers to the act of inferring someone’s inner state, such as their emotions and thoughts. Previous work also demonstrated that ToM performance declines across age, but the mechanisms underlying this are not well-understood. The brain regions underlying ToM are generally in the default mode network (DMN) – a group of brain regions particularly vulnerable to pathological aging. Recent work suggests that declines in functional connectivity (FC; correlations between brain regions) during resting state (a period of undirected thought) predict age deficits in ToM. However, these findings come from aggregated FC, ignoring potentially informative details of dynamic changes during resting state. Researching these details may provide more specificity related to social cognitive aging. To test this, 35 older adults (OA; M = 75.61; 22 female) and 40 young adults (YA; M = 21.58; 25 female) underwent resting state and task-based fMRI. During the task, they completed a standard ToM task. We conducted time-varying functional connectivity analyses in the DMN to identify dynamic changes over time. Overall, OA had more variability than YA, but variability benefitted YAs, and not OAs. This occurred specifically in a DMN subnetwork associated with contextual information in memory. These results suggest that variability is useful, but only to an extent. With respect to ToM, variability may promote how YA integrate contextual information to memory, but is ineffective for OA. |
format | Online Article Text |
id | pubmed-9771047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-97710472023-01-24 AGE-RELATED DIFFERENCES IN THEORY OF MIND: A TIME-VARYING FUNCTIONAL CONNECTIVITY APPROACH Rincon, Samuel Naranjo Betzel, Richard Krendl, Anne Innov Aging Abstracts Theory of Mind (ToM) refers to the act of inferring someone’s inner state, such as their emotions and thoughts. Previous work also demonstrated that ToM performance declines across age, but the mechanisms underlying this are not well-understood. The brain regions underlying ToM are generally in the default mode network (DMN) – a group of brain regions particularly vulnerable to pathological aging. Recent work suggests that declines in functional connectivity (FC; correlations between brain regions) during resting state (a period of undirected thought) predict age deficits in ToM. However, these findings come from aggregated FC, ignoring potentially informative details of dynamic changes during resting state. Researching these details may provide more specificity related to social cognitive aging. To test this, 35 older adults (OA; M = 75.61; 22 female) and 40 young adults (YA; M = 21.58; 25 female) underwent resting state and task-based fMRI. During the task, they completed a standard ToM task. We conducted time-varying functional connectivity analyses in the DMN to identify dynamic changes over time. Overall, OA had more variability than YA, but variability benefitted YAs, and not OAs. This occurred specifically in a DMN subnetwork associated with contextual information in memory. These results suggest that variability is useful, but only to an extent. With respect to ToM, variability may promote how YA integrate contextual information to memory, but is ineffective for OA. Oxford University Press 2022-12-20 /pmc/articles/PMC9771047/ http://dx.doi.org/10.1093/geroni/igac059.2080 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Rincon, Samuel Naranjo Betzel, Richard Krendl, Anne AGE-RELATED DIFFERENCES IN THEORY OF MIND: A TIME-VARYING FUNCTIONAL CONNECTIVITY APPROACH |
title | AGE-RELATED DIFFERENCES IN THEORY OF MIND: A TIME-VARYING FUNCTIONAL CONNECTIVITY APPROACH |
title_full | AGE-RELATED DIFFERENCES IN THEORY OF MIND: A TIME-VARYING FUNCTIONAL CONNECTIVITY APPROACH |
title_fullStr | AGE-RELATED DIFFERENCES IN THEORY OF MIND: A TIME-VARYING FUNCTIONAL CONNECTIVITY APPROACH |
title_full_unstemmed | AGE-RELATED DIFFERENCES IN THEORY OF MIND: A TIME-VARYING FUNCTIONAL CONNECTIVITY APPROACH |
title_short | AGE-RELATED DIFFERENCES IN THEORY OF MIND: A TIME-VARYING FUNCTIONAL CONNECTIVITY APPROACH |
title_sort | age-related differences in theory of mind: a time-varying functional connectivity approach |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771047/ http://dx.doi.org/10.1093/geroni/igac059.2080 |
work_keys_str_mv | AT rinconsamuelnaranjo agerelateddifferencesintheoryofmindatimevaryingfunctionalconnectivityapproach AT betzelrichard agerelateddifferencesintheoryofmindatimevaryingfunctionalconnectivityapproach AT krendlanne agerelateddifferencesintheoryofmindatimevaryingfunctionalconnectivityapproach |