Cargando…

THE ASSOCIATION BETWEEN FRAILTY AND PERCEIVED FATIGABILITY IN THE LONG LIFE FAMILY STUDY

Higher levels of frailty, quantified by a frailty index (FI), may be linked to fatigue severity as tasks become more physically and mentally demanding. However, the association between frailty and fatigability—quantification of vulnerability to fatigue in relation to specific intensity and duration...

Descripción completa

Detalles Bibliográficos
Autores principales: Schumacher, Benjamin, Kehler, Dustin, Kulminski, Alexander, Andersen, Stacy, Gmelin, Theresa, Christensen, Kaare, Wojczynski, Mary, Glynn, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771113/
http://dx.doi.org/10.1093/geroni/igac059.3089
_version_ 1784854749623877632
author Schumacher, Benjamin
Kehler, Dustin
Kulminski, Alexander
Andersen, Stacy
Gmelin, Theresa
Christensen, Kaare
Wojczynski, Mary
Glynn, Nancy
author_facet Schumacher, Benjamin
Kehler, Dustin
Kulminski, Alexander
Andersen, Stacy
Gmelin, Theresa
Christensen, Kaare
Wojczynski, Mary
Glynn, Nancy
author_sort Schumacher, Benjamin
collection PubMed
description Higher levels of frailty, quantified by a frailty index (FI), may be linked to fatigue severity as tasks become more physically and mentally demanding. However, the association between frailty and fatigability—quantification of vulnerability to fatigue in relation to specific intensity and duration of activities—has not been assessed. Using cross-sectional data from the Long Life Family Study Visit 2 (2014–2017; n=2,524; mean age +/- standard deviation 71.4+/-11.2 years; 55% women; 99% White), we examined the association between a 79-item FI (ratio of number of health problems reported (numerator) out of the 79 (denominator); higher percentage=greater frailty) and perceived physical and mental fatigability using the Pittsburgh Fatigability Scale (PFS) (range 0–50; higher scores=greater fatigability). Mean+/-SD FI scores were 0.08+/-0.06 and mean+/-SD PFS Physical and Mental scores were 13.7+/-9.6 (39.5% more severe, >=15) and 7.9+/-8.9 (22.8% more severe, >=13), respectively. Both PFS subscale scores were higher for each 0.10 increment in FI. Mean PFS scores were 10.7 and 34.2 (Physical) and 5.7 and 28.8 (Mental) for FI scores of < 0.10 (non-frail) and ≥0.30 (moderate-severely frail), respectively. In mixed effects models, a 0.03 higher FI score (accepted clinically meaningful increase in FI) was associated with 1.9-point higher PFS Physical (95% confidence interval (CI) 1.7–2.1) and 1.7-point higher PFS Mental (95% CI 1.5–1.9) scores after accounting for family structure and adjusting for age, sex, field center, body mass index, smoking status, education, and marital status. Individuals with higher FI scores may benefit from targeted interventions to mitigate further poor health outcomes.
format Online
Article
Text
id pubmed-9771113
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-97711132023-01-24 THE ASSOCIATION BETWEEN FRAILTY AND PERCEIVED FATIGABILITY IN THE LONG LIFE FAMILY STUDY Schumacher, Benjamin Kehler, Dustin Kulminski, Alexander Andersen, Stacy Gmelin, Theresa Christensen, Kaare Wojczynski, Mary Glynn, Nancy Innov Aging Late Breaking Abstracts Higher levels of frailty, quantified by a frailty index (FI), may be linked to fatigue severity as tasks become more physically and mentally demanding. However, the association between frailty and fatigability—quantification of vulnerability to fatigue in relation to specific intensity and duration of activities—has not been assessed. Using cross-sectional data from the Long Life Family Study Visit 2 (2014–2017; n=2,524; mean age +/- standard deviation 71.4+/-11.2 years; 55% women; 99% White), we examined the association between a 79-item FI (ratio of number of health problems reported (numerator) out of the 79 (denominator); higher percentage=greater frailty) and perceived physical and mental fatigability using the Pittsburgh Fatigability Scale (PFS) (range 0–50; higher scores=greater fatigability). Mean+/-SD FI scores were 0.08+/-0.06 and mean+/-SD PFS Physical and Mental scores were 13.7+/-9.6 (39.5% more severe, >=15) and 7.9+/-8.9 (22.8% more severe, >=13), respectively. Both PFS subscale scores were higher for each 0.10 increment in FI. Mean PFS scores were 10.7 and 34.2 (Physical) and 5.7 and 28.8 (Mental) for FI scores of < 0.10 (non-frail) and ≥0.30 (moderate-severely frail), respectively. In mixed effects models, a 0.03 higher FI score (accepted clinically meaningful increase in FI) was associated with 1.9-point higher PFS Physical (95% confidence interval (CI) 1.7–2.1) and 1.7-point higher PFS Mental (95% CI 1.5–1.9) scores after accounting for family structure and adjusting for age, sex, field center, body mass index, smoking status, education, and marital status. Individuals with higher FI scores may benefit from targeted interventions to mitigate further poor health outcomes. Oxford University Press 2022-12-20 /pmc/articles/PMC9771113/ http://dx.doi.org/10.1093/geroni/igac059.3089 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Late Breaking Abstracts
Schumacher, Benjamin
Kehler, Dustin
Kulminski, Alexander
Andersen, Stacy
Gmelin, Theresa
Christensen, Kaare
Wojczynski, Mary
Glynn, Nancy
THE ASSOCIATION BETWEEN FRAILTY AND PERCEIVED FATIGABILITY IN THE LONG LIFE FAMILY STUDY
title THE ASSOCIATION BETWEEN FRAILTY AND PERCEIVED FATIGABILITY IN THE LONG LIFE FAMILY STUDY
title_full THE ASSOCIATION BETWEEN FRAILTY AND PERCEIVED FATIGABILITY IN THE LONG LIFE FAMILY STUDY
title_fullStr THE ASSOCIATION BETWEEN FRAILTY AND PERCEIVED FATIGABILITY IN THE LONG LIFE FAMILY STUDY
title_full_unstemmed THE ASSOCIATION BETWEEN FRAILTY AND PERCEIVED FATIGABILITY IN THE LONG LIFE FAMILY STUDY
title_short THE ASSOCIATION BETWEEN FRAILTY AND PERCEIVED FATIGABILITY IN THE LONG LIFE FAMILY STUDY
title_sort association between frailty and perceived fatigability in the long life family study
topic Late Breaking Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771113/
http://dx.doi.org/10.1093/geroni/igac059.3089
work_keys_str_mv AT schumacherbenjamin theassociationbetweenfrailtyandperceivedfatigabilityinthelonglifefamilystudy
AT kehlerdustin theassociationbetweenfrailtyandperceivedfatigabilityinthelonglifefamilystudy
AT kulminskialexander theassociationbetweenfrailtyandperceivedfatigabilityinthelonglifefamilystudy
AT andersenstacy theassociationbetweenfrailtyandperceivedfatigabilityinthelonglifefamilystudy
AT gmelintheresa theassociationbetweenfrailtyandperceivedfatigabilityinthelonglifefamilystudy
AT christensenkaare theassociationbetweenfrailtyandperceivedfatigabilityinthelonglifefamilystudy
AT wojczynskimary theassociationbetweenfrailtyandperceivedfatigabilityinthelonglifefamilystudy
AT glynnnancy theassociationbetweenfrailtyandperceivedfatigabilityinthelonglifefamilystudy
AT schumacherbenjamin associationbetweenfrailtyandperceivedfatigabilityinthelonglifefamilystudy
AT kehlerdustin associationbetweenfrailtyandperceivedfatigabilityinthelonglifefamilystudy
AT kulminskialexander associationbetweenfrailtyandperceivedfatigabilityinthelonglifefamilystudy
AT andersenstacy associationbetweenfrailtyandperceivedfatigabilityinthelonglifefamilystudy
AT gmelintheresa associationbetweenfrailtyandperceivedfatigabilityinthelonglifefamilystudy
AT christensenkaare associationbetweenfrailtyandperceivedfatigabilityinthelonglifefamilystudy
AT wojczynskimary associationbetweenfrailtyandperceivedfatigabilityinthelonglifefamilystudy
AT glynnnancy associationbetweenfrailtyandperceivedfatigabilityinthelonglifefamilystudy