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Chuna manual therapy for the treatment of anorexia in children: A PRISMA-compliant systematic review and meta-analysis
Anorexia in children can cause malnutrition, low immunity, growth retardation, and various secondary infections, resulting in a huge burden on society. In East Asia, Chuna manual therapy has been widely used for the treatment of childhood anorexia. We aimed to comprehensively evaluate the effects of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771173/ https://www.ncbi.nlm.nih.gov/pubmed/36550806 http://dx.doi.org/10.1097/MD.0000000000031746 |
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author | Lee, Hesol Lee, Boram Lee, Sun Haeng Chang, Gyu Tae |
author_facet | Lee, Hesol Lee, Boram Lee, Sun Haeng Chang, Gyu Tae |
author_sort | Lee, Hesol |
collection | PubMed |
description | Anorexia in children can cause malnutrition, low immunity, growth retardation, and various secondary infections, resulting in a huge burden on society. In East Asia, Chuna manual therapy has been widely used for the treatment of childhood anorexia. We aimed to comprehensively evaluate the effects of Chuna manual therapy for treating childhood anorexia. METHODS: Twelve databases were comprehensively searched from their inception to September 13, 2022. Only randomized controlled trials assessing Chuna manual therapy for the treatment of childhood anorexia were included. The methodological quality of the included studies was assessed using the Cochrane risk-of-bias tool. The quality of evidence for each main outcome was evaluated using the grading of recommendations assessment, development, and evaluation approach. A meta-analysis was performed, and the pooled data were presented as risk ratios (RRs) with 95% confidence intervals (CIs) for dichotomous outcomes. RESULTS: Twenty-five RCTs involving 2230 participants were included. The meta-analysis showed that Chuna manual therapy had a higher total effective rate (TER) based on anorexia symptoms than that of lysine inositol and vitamin B12 (RR: 1.53, 95% CI: 1.28–1.84), multi-enzyme and multi-vitamin (RR: 1.21, 95% CI: 1.11–1.33), and zinc calcium gluconate (RR: 1.22, 95% CI: 1.06–1.39). There was no significant difference in total effective rate between Chuna manual therapy and zinc gluconate plus lysine. No adverse events associated with Chuna manual therapy were reported. Overall, the included studies had an unclear risk of bias, and the quality of evidence was generally moderate to low. CONCLUSION: Current evidence showed that Chuna manual therapy may be effective and safe for improving anorexia symptoms, especially compared with lysine inositol and vitamin B12, multi-enzyme plus multi-vitamin, and zinc calcium gluconate. However, owing to the low methodological quality of the included studies, more rigorous, high-quality RCTs are required on this topic. |
format | Online Article Text |
id | pubmed-9771173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-97711732022-12-22 Chuna manual therapy for the treatment of anorexia in children: A PRISMA-compliant systematic review and meta-analysis Lee, Hesol Lee, Boram Lee, Sun Haeng Chang, Gyu Tae Medicine (Baltimore) 3800 Anorexia in children can cause malnutrition, low immunity, growth retardation, and various secondary infections, resulting in a huge burden on society. In East Asia, Chuna manual therapy has been widely used for the treatment of childhood anorexia. We aimed to comprehensively evaluate the effects of Chuna manual therapy for treating childhood anorexia. METHODS: Twelve databases were comprehensively searched from their inception to September 13, 2022. Only randomized controlled trials assessing Chuna manual therapy for the treatment of childhood anorexia were included. The methodological quality of the included studies was assessed using the Cochrane risk-of-bias tool. The quality of evidence for each main outcome was evaluated using the grading of recommendations assessment, development, and evaluation approach. A meta-analysis was performed, and the pooled data were presented as risk ratios (RRs) with 95% confidence intervals (CIs) for dichotomous outcomes. RESULTS: Twenty-five RCTs involving 2230 participants were included. The meta-analysis showed that Chuna manual therapy had a higher total effective rate (TER) based on anorexia symptoms than that of lysine inositol and vitamin B12 (RR: 1.53, 95% CI: 1.28–1.84), multi-enzyme and multi-vitamin (RR: 1.21, 95% CI: 1.11–1.33), and zinc calcium gluconate (RR: 1.22, 95% CI: 1.06–1.39). There was no significant difference in total effective rate between Chuna manual therapy and zinc gluconate plus lysine. No adverse events associated with Chuna manual therapy were reported. Overall, the included studies had an unclear risk of bias, and the quality of evidence was generally moderate to low. CONCLUSION: Current evidence showed that Chuna manual therapy may be effective and safe for improving anorexia symptoms, especially compared with lysine inositol and vitamin B12, multi-enzyme plus multi-vitamin, and zinc calcium gluconate. However, owing to the low methodological quality of the included studies, more rigorous, high-quality RCTs are required on this topic. Lippincott Williams & Wilkins 2022-12-16 /pmc/articles/PMC9771173/ /pubmed/36550806 http://dx.doi.org/10.1097/MD.0000000000031746 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 3800 Lee, Hesol Lee, Boram Lee, Sun Haeng Chang, Gyu Tae Chuna manual therapy for the treatment of anorexia in children: A PRISMA-compliant systematic review and meta-analysis |
title | Chuna manual therapy for the treatment of anorexia in children: A PRISMA-compliant systematic review and meta-analysis |
title_full | Chuna manual therapy for the treatment of anorexia in children: A PRISMA-compliant systematic review and meta-analysis |
title_fullStr | Chuna manual therapy for the treatment of anorexia in children: A PRISMA-compliant systematic review and meta-analysis |
title_full_unstemmed | Chuna manual therapy for the treatment of anorexia in children: A PRISMA-compliant systematic review and meta-analysis |
title_short | Chuna manual therapy for the treatment of anorexia in children: A PRISMA-compliant systematic review and meta-analysis |
title_sort | chuna manual therapy for the treatment of anorexia in children: a prisma-compliant systematic review and meta-analysis |
topic | 3800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771173/ https://www.ncbi.nlm.nih.gov/pubmed/36550806 http://dx.doi.org/10.1097/MD.0000000000031746 |
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