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Transcutaneous auricular vagus nerve stimulation in disorders of consciousness: A mini-narrative review

In this mini review, 6 studies that investigated the effects of transcutaneous auricular vagus nerve stimulation (taVNS) in patients with disorders of consciousness (DOC) were reviewed. Generally, the application of taVNS in patients with DOC appears to be effective (positive results in 5 of 6 studi...

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Autores principales: Jang, Sung Ho, Cho, Min Jye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771208/
https://www.ncbi.nlm.nih.gov/pubmed/36550876
http://dx.doi.org/10.1097/MD.0000000000031808
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author Jang, Sung Ho
Cho, Min Jye
author_facet Jang, Sung Ho
Cho, Min Jye
author_sort Jang, Sung Ho
collection PubMed
description In this mini review, 6 studies that investigated the effects of transcutaneous auricular vagus nerve stimulation (taVNS) in patients with disorders of consciousness (DOC) were reviewed. Generally, the application of taVNS in patients with DOC appears to be effective (positive results in 5 of 6 studies) and safe. Furthermore, 4 studies that evaluated changes in the brain following taVNS reported positive results (2 studies, functional magnetic resonance imaging and 2 studies, electroencephalography). Based on our review of the 6 studies, we believe that research and clinical application of taVNS in DOC are in the initial stages and have the following limitations. First, there is a shortage of studies on this topic, with only 6 studies, 2 of which were case reports. Second, 5 studies were performed without control or sham groups. Third, there was no standardization of treatment schedules and electrical stimulation parameters. Therefore, further studies to overcome the above limitations should be encouraged; further original studies involving a larger number of patients in the control or sham groups are needed. However, studies on the optimal conditions (treatment schedule and electrical stimulation parameters) for taVNS in patients with DOC are necessary. Furthermore, neuroimaging studies should be undertaken to elucidate the neurological mechanisms for the recovery of impaired consciousness in DOC and the lasting effects of taVNS on the brain.
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spelling pubmed-97712082022-12-22 Transcutaneous auricular vagus nerve stimulation in disorders of consciousness: A mini-narrative review Jang, Sung Ho Cho, Min Jye Medicine (Baltimore) 5300 In this mini review, 6 studies that investigated the effects of transcutaneous auricular vagus nerve stimulation (taVNS) in patients with disorders of consciousness (DOC) were reviewed. Generally, the application of taVNS in patients with DOC appears to be effective (positive results in 5 of 6 studies) and safe. Furthermore, 4 studies that evaluated changes in the brain following taVNS reported positive results (2 studies, functional magnetic resonance imaging and 2 studies, electroencephalography). Based on our review of the 6 studies, we believe that research and clinical application of taVNS in DOC are in the initial stages and have the following limitations. First, there is a shortage of studies on this topic, with only 6 studies, 2 of which were case reports. Second, 5 studies were performed without control or sham groups. Third, there was no standardization of treatment schedules and electrical stimulation parameters. Therefore, further studies to overcome the above limitations should be encouraged; further original studies involving a larger number of patients in the control or sham groups are needed. However, studies on the optimal conditions (treatment schedule and electrical stimulation parameters) for taVNS in patients with DOC are necessary. Furthermore, neuroimaging studies should be undertaken to elucidate the neurological mechanisms for the recovery of impaired consciousness in DOC and the lasting effects of taVNS on the brain. Lippincott Williams & Wilkins 2022-12-16 /pmc/articles/PMC9771208/ /pubmed/36550876 http://dx.doi.org/10.1097/MD.0000000000031808 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5300
Jang, Sung Ho
Cho, Min Jye
Transcutaneous auricular vagus nerve stimulation in disorders of consciousness: A mini-narrative review
title Transcutaneous auricular vagus nerve stimulation in disorders of consciousness: A mini-narrative review
title_full Transcutaneous auricular vagus nerve stimulation in disorders of consciousness: A mini-narrative review
title_fullStr Transcutaneous auricular vagus nerve stimulation in disorders of consciousness: A mini-narrative review
title_full_unstemmed Transcutaneous auricular vagus nerve stimulation in disorders of consciousness: A mini-narrative review
title_short Transcutaneous auricular vagus nerve stimulation in disorders of consciousness: A mini-narrative review
title_sort transcutaneous auricular vagus nerve stimulation in disorders of consciousness: a mini-narrative review
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771208/
https://www.ncbi.nlm.nih.gov/pubmed/36550876
http://dx.doi.org/10.1097/MD.0000000000031808
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